INT136134

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Context Info
Confidence 0.35
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.64
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mc4r) plasma membrane (Mc4r) signal transducer activity (Mc4r)
Anatomy Link Frequency
arcuate nucleus 2
Mc4r (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 1 87.12 High High
Potency 5 54.28 Quite High
Endogenous opioid 1 47.36 Quite Low
MU agonist 1 42.80 Quite Low
Opioid 4 31.28 Quite Low
antagonist 3 30.72 Quite Low
narcan 1 29.84 Quite Low
Neuropeptide 1 26.64 Quite Low
agonist 13 5.00 Very Low Very Low Very Low
5HT 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperphagia 5 98.82 Very High Very High Very High
Metabolic Disorder 1 76.28 Quite High
Metabolic Syndrome 1 73.40 Quite High
Obesity 14 71.56 Quite High
Disease 2 5.04 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Overweight 1 5.00 Very Low Very Low Very Low
Loss Of Sense Of Smell 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We next examined the kinetics of internalization of MC4R as measured by the loss of cell-surface MC4R expression.
Negative_regulation (loss) of Gene_expression (expression) of MC4R
1) Confidence 0.35 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1930153 Disease Relevance 0 Pain Relevance 0.03
HF (58% fat) diet promoted transient ( approximately 8 wk) hyperphagia and decreased food efficiency in 11 beta-HSD1-/- mice and decreased melanocortin-4 receptor mRNA expression in control but not 11 beta-HSD1-/- mice. 11 beta-HSD1-/- mice showed a HF-mediated up-regulation of the orexigenic agouti-related peptide (AGRP) mRNA in the arcuate nucleus which paralleled the transient HF hyperphagia.
Negative_regulation (decreased) of Gene_expression (expression) of melanocortin-4 receptor mRNA in arcuate nucleus associated with hyperphagia
2) Confidence 0.32 Published 2006 Journal Endocrinology Section Abstract Doc Link 16763061 Disease Relevance 0.64 Pain Relevance 0.04

General Comments

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