INT136135

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Context Info
Confidence 0.51
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.20
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Hsd11b1) endoplasmic reticulum (Hsd11b1) lipid metabolic process (Hsd11b1)
cytoplasm (Hsd11b1)
Hsd11b1 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 1 99.00 Very High Very High Very High
antagonist 1 98.82 Very High Very High Very High
Opioid 2 98.60 Very High Very High Very High
MU agonist 1 95.88 Very High Very High Very High
Endogenous opioid 1 89.64 High High
cocaine 1 47.76 Quite Low
Disease Link Frequency Relevance Heat
Hyperphagia 5 75.00 Quite High
Metabolic Disorder 1 36.92 Quite Low
Metabolic Syndrome 1 34.04 Quite Low
Obesity 1 32.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of HF-fed mice with the mu opioid agonist DAMGO recapitulated the HF-induced dissociation of arcuate AGRP expression between control and 11 beta-HSD1-/- mice, whereas the opioid antagonist naloxone given with HF induced a rise in arcuate AGRP and blocked HF-diet induction of 11 beta-HSD1.
Negative_regulation (blocked) of Positive_regulation (induction) of beta-HSD1 associated with mu agonist, antagonist, narcan and opioid
1) Confidence 0.51 Published 2006 Journal Endocrinology Section Abstract Doc Link 16763061 Disease Relevance 0.20 Pain Relevance 0.47

General Comments

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