INT136136

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.45
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Hsd11b1) endoplasmic reticulum (Hsd11b1) lipid metabolic process (Hsd11b1)
cytoplasm (Hsd11b1)
Anatomy Link Frequency
arcuate nucleus 1
Hsd11b1 (Mus musculus)
Pain Link Frequency Relevance Heat
Endogenous opioid 1 90.16 High High
MU agonist 1 85.60 High High
Opioid 2 74.08 Quite High
antagonist 1 73.52 Quite High
narcan 1 72.64 Quite High
cocaine 1 64.96 Quite High
Disease Link Frequency Relevance Heat
Hyperphagia 5 88.56 High High
Metabolic Disorder 1 54.12 Quite High
Metabolic Syndrome 1 51.24 Quite High
Obesity 1 49.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This regulatory pattern was unexpected because glucocorticoids increase AGRP, suggesting an alternate hyperphagic mechanism despite partial colocalization of 11 beta-HSD1 and AGRP in arcuate nucleus cells.
Spec (partial) Localization (colocalization) of beta-HSD1 in arcuate nucleus
1) Confidence 0.69 Published 2006 Journal Endocrinology Section Abstract Doc Link 16763061 Disease Relevance 0.45 Pain Relevance 0.41

General Comments

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