INT136139

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Context Info
Confidence 0.70
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.83
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mc4r) plasma membrane (Mc4r) signal transducer activity (Mc4r)
Anatomy Link Frequency
hypothalamus 1
fat 1
brain 1
Mc4r (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 7 100.00 Very High Very High Very High
cytokine 13 91.00 High High
agonist 22 89.04 High High
Central nervous system 31 87.28 High High
gABA 16 84.64 Quite High
Cholecystokinin 16 80.44 Quite High
Action potential 8 78.00 Quite High
antagonist 24 66.08 Quite High
Inflammation 5 48.68 Quite Low
Inflammatory response 1 43.96 Quite Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 104 97.04 Very High Very High Very High
Leukemia 1 93.96 High High
Hyperphagia 12 92.48 High High
Metabolic Disorder 2 90.52 High High
Metabolic Syndrome 3 87.64 High High
Obesity 116 85.80 High High
Sprains And Strains 10 82.16 Quite High
Appetite Loss 65 81.12 Quite High
Anorexia 28 69.68 Quite High
Cardiovascular Disorder Under Development 1 64.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite this, mc3r and mc4r mRNA are abundant (Table 3; [90,118]).
Transcription (abundant) of mc4r
1) Confidence 0.70 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.13 Pain Relevance 0.12
A large proportion of NPY neurones in the rat hypothalamus express mc3r mRNA while a much lower number of NPY neurones express mc4r mRNA, suggesting that POMC neurones may directly modulate the activity of the hypothalamic NPY system too, mainly through activation of MC3R [61].
Transcription (express) of mc4r in hypothalamus
2) Confidence 0.70 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.40 Pain Relevance 0.30
In addition to being expressed in the brain, Mc4r mRNA expression has also been demonstrated in peripheral systems, including the heart and lung (Mountjoy et al. 2003).
Transcription (expression) of Mc4r in brain
3) Confidence 0.69 Published 2010 Journal The Journal of Endocrinology Section Body Doc Link PMC2887273 Disease Relevance 0.64 Pain Relevance 0.16
We show that 11 beta-HSD1-/- mice express lower hypothalamic mRNA levels of the anorexigenic cocaine and amphetamine-regulated transcript and melanocortin-4 receptor, but higher levels of the orexigenic melanin-concentrating hormone mRNAs than controls (C57BL/6J) on a low-fat diet (11% fat).
Transcription (levels) of melanocortin-4 receptor in fat associated with cocaine
4) Confidence 0.38 Published 2006 Journal Endocrinology Section Abstract Doc Link 16763061 Disease Relevance 0.66 Pain Relevance 0.05

General Comments

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