INT136140

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Context Info
Confidence 0.60
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 1.35
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Hsd11b1) endoplasmic reticulum (Hsd11b1) lipid metabolic process (Hsd11b1)
cytoplasm (Hsd11b1)
Anatomy Link Frequency
arcuate nucleus 1
Hsd11b1 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 3 98.68 Very High Very High Very High
antagonist 3 98.50 Very High Very High Very High
Opioid 6 98.28 Very High Very High Very High
MU agonist 3 95.56 Very High Very High Very High
Endogenous opioid 3 89.00 High High
cocaine 3 73.96 Quite High
Disease Link Frequency Relevance Heat
Hyperphagia 15 97.56 Very High Very High Very High
Obesity 3 88.48 High High
Metabolic Syndrome 3 86.80 High High
Metabolic Disorder 3 83.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, control mice showed a rapid (48 h) HF-mediated increase in arcuate 11 beta-HSD1 associated with subsequent down-regulation of AGRP.
Positive_regulation (increase) of beta-HSD1
1) Confidence 0.60 Published 2006 Journal Endocrinology Section Abstract Doc Link 16763061 Disease Relevance 0.56 Pain Relevance 0.29
Treatment of HF-fed mice with the mu opioid agonist DAMGO recapitulated the HF-induced dissociation of arcuate AGRP expression between control and 11 beta-HSD1-/- mice, whereas the opioid antagonist naloxone given with HF induced a rise in arcuate AGRP and blocked HF-diet induction of 11 beta-HSD1.
Positive_regulation (induction) of beta-HSD1 associated with mu agonist, antagonist, narcan and opioid
2) Confidence 0.60 Published 2006 Journal Endocrinology Section Abstract Doc Link 16763061 Disease Relevance 0.20 Pain Relevance 0.47
11 beta-hydroxysteroid dehydrogenase type 1 induction in the arcuate nucleus by high-fat feeding: A novel constraint to hyperphagia?
Positive_regulation (induction) of beta-hydroxysteroid dehydrogenase type 1 in arcuate nucleus associated with hyperphagia
3) Confidence 0.40 Published 2006 Journal Endocrinology Section Title Doc Link 16763061 Disease Relevance 0.59 Pain Relevance 0.04

General Comments

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