INT136172

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Context Info
Confidence 0.21
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Drd1a) intracellular (Drd1a) signal transducer activity (Drd1a)
cell proliferation (NPY) signal transduction (Drd1a) extracellular space (NPY)
Anatomy Link Frequency
nucleus accumbens 2
NPY (Homo sapiens)
Drd1a (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 3 100.00 Very High Very High Very High
Opioid 1 99.82 Very High Very High Very High
Morphine 8 98.46 Very High Very High Very High
agonist 1 89.28 High High
Dopamine 1 84.32 Quite High
Neuropeptide 2 75.00 Quite High
antagonist 1 66.04 Quite High
Central nervous system 1 46.96 Quite Low
mu opioid receptor 1 45.76 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Collectively, these findings demonstrate that NPY Y1 receptors mediate morphine's suppressive effect on NK activity and further suggest that opioid-induced increases in nucleus accumbens D1 receptor activation inhibit splenic NK activity via NPY released from the sympathetic nervous system.
NPY Negative_regulation (inhibit) of Positive_regulation (increases) of D1 receptor in nucleus accumbens associated with nucleus accumbens, opioid and morphine
1) Confidence 0.21 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16766046 Disease Relevance 0 Pain Relevance 0.91

General Comments

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