INT136179

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 7.06
Pain Relevance 4.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2RX4) transport (P2RX4) plasma membrane (P2RX4)
response to stress (P2RX4)
Anatomy Link Frequency
microglia 4
nerve 1
neurons 1
P2RX4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Peripheral nerve injury 12 99.82 Very High Very High Very High
Stimulus evoked pain 13 99.22 Very High Very High Very High
allodynia 13 98.52 Very High Very High Very High
Dorsal horn 26 97.76 Very High Very High Very High
intrathecal 6 97.32 Very High Very High Very High
Spinal cord 34 96.20 Very High Very High Very High
Pain 58 95.92 Very High Very High Very High
Neuronal excitability 1 94.56 High High
Inflammation 25 94.28 High High
Inflammatory mediators 2 93.92 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 51 99.82 Very High Very High Very High
Injury 18 99.72 Very High Very High Very High
Hypersensitivity 17 99.22 Very High Very High Very High
Pain 76 98.88 Very High Very High Very High
Neuropathic Pain 116 98.52 Very High Very High Very High
Nociception 7 98.28 Very High Very High Very High
Hypertrophy 4 96.20 Very High Very High Very High
INFLAMMATION 30 94.28 High High
Infection 42 87.28 High High
Mycobacterial Infection 12 87.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent findings suggest that activation of P2X4 receptors evokes release of brain-derived neurotrophic factor from microglia and that this mediates microglia-neuron signaling leading to pain hypersensitivity.
Positive_regulation (activation) of P2X4 in microglia associated with hypersensitivity and stimulus evoked pain
1) Confidence 0.67 Published 2006 Journal Pflugers Arch. Section Abstract Doc Link 16767466 Disease Relevance 0.87 Pain Relevance 0.50
The activation of P2X4 receptors releases brain-derived neurotrophic factor from microglia; this mediates the signaling from microglia to neurons, which in turn leads to pain hypersensitivity.
Positive_regulation (activation) of P2X4 in neurons associated with hypersensitivity and stimulus evoked pain
2) Confidence 0.67 Published 2007 Journal Brain Nerve Section Abstract Doc Link 17886477 Disease Relevance 1.04 Pain Relevance 0.62
Furthermore, P2X4 receptors that which are upregulated in activated microglia, have been found to be essential molecular mediators.
Positive_regulation (upregulated) of P2X4 in microglia
3) Confidence 0.45 Published 2007 Journal Brain Nerve Section Abstract Doc Link 17886477 Disease Relevance 1.06 Pain Relevance 0.63
Moreover, it was found that reducing the upregulation of P2X4R protein in spinal microglia by means of intrathecally administered antisense oligodeoxynucleotide targeting P2X4R prevented the development of the nerve injury-induced tactile allodynia.
Positive_regulation (upregulation) of P2X4R in nerve associated with brush evoked pain and nervous system injury
4) Confidence 0.41 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096535 Disease Relevance 1.11 Pain Relevance 0.73
The sufficiency of P2X4R activation in microglia for the development of allodynia was demonstrated by intrathecal administration of activated, cultured microglia in which these receptors had been stimulated in vitro by ATP [59].
Positive_regulation (activation) of P2X4R in microglia associated with allodynia and intrathecal
5) Confidence 0.27 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096535 Disease Relevance 1.02 Pain Relevance 0.73
Activation of P2X3, P2X2/3, P2X4, P2X7, and P2Y (e.g.
Positive_regulation (Activation) of P2X4
6) Confidence 0.22 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0.59 Pain Relevance 0.48
The late phase of BDNF release and accumulation, but not the early phase of release, are suppressed by inhibiting transcription and translation, indicating that activation of P2X4R causes an initial release of a pre-existing pool of BDNF followed by an increase in de novo synthesis of BDNF.
Positive_regulation (activation) of P2X4R
7) Confidence 0.15 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19295157 Disease Relevance 0.47 Pain Relevance 0.29
Together, our findings provide a unifying mechanism for pain hypersensitivity after peripheral nerve injury through P2X4R-evoked increase in Ca(2+) and activation of p38-MAPK leading to the synthesis and exocytotic release of BDNF from microglia.
Positive_regulation (increase) of P2X4R-evoked in microglia associated with nervous system injury, hypersensitivity, stimulus evoked pain and peripheral nerve injury
8) Confidence 0.09 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19295157 Disease Relevance 0.40 Pain Relevance 0.20
This effect was initially ascribed to the P2X7 receptor, but now, P2X7 activity is known to be blocked by extracellular Zn2+, while the activity of another purinergic receptor, P2X4, is potentiated by Zn2+ [24].
Positive_regulation (potentiated) of P2X4
9) Confidence 0.09 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096763 Disease Relevance 0.50 Pain Relevance 0.09

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