INT136190

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Context Info
Confidence 0.61
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.75
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn1) plasma membrane (Accn1)
Anatomy Link Frequency
neurons 2
muscle 1
dorsal root ganglions 1
Accn1 (Mus musculus)
Pain Link Frequency Relevance Heat
ASIC 23 100.00 Very High Very High Very High
Hyperalgesia 17 99.28 Very High Very High Very High
Inflammation 13 99.28 Very High Very High Very High
Root ganglion neuron 1 98.60 Very High Very High Very High
spinal dorsal horn 1 95.84 Very High Very High Very High
Mechanotransduction 6 86.64 High High
Visceral pain 5 80.96 Quite High
Pain 6 75.00 Quite High
nociceptor 3 75.00 Quite High
TRP channel 1 63.20 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 17 99.28 Very High Very High Very High
INFLAMMATION 10 99.28 Very High Very High Very High
Ganglion Cysts 4 98.40 Very High Very High Very High
Hypercalcemia 3 97.84 Very High Very High Very High
Acidosis 3 97.68 Very High Very High Very High
Osteoporosis 3 97.20 Very High Very High Very High
Targeted Disruption 2 92.60 High High
Pain 5 75.00 Quite High
Injury 3 75.00 Quite High
Bone Cancer 1 54.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Single afferent fiber recordings were made in vitro from mouse high threshold colonic thoracolumbar splanchnic afferents and low threshold gastroesophageal vagal afferents. mRNA expression of ASIC subtypes was compared between colonic and gastroesophageal afferents by quantitative RT-PCR of transcripts following laser capture microdissection of retrogradely labeled cell bodies.
Transcription (expression) of ASIC associated with asic
1) Confidence 0.61 Published 2007 Journal Pain Section Abstract Doc Link 17467171 Disease Relevance 0.09 Pain Relevance 0.17
We examined the expression of ASIC1, ASIC2, and ASIC3 mRNAs in lumbar dorsal root ganglion neurons before and 24 hours after carrageenan-induced muscle inflammation.
Spec (examined) Transcription (expression) of ASIC2 in muscle associated with ganglion cysts, inflammation and root ganglion neuron
2) Confidence 0.50 Published 2010 Journal J Pain Section Abstract Doc Link 20015700 Disease Relevance 0.96 Pain Relevance 0.44
In particular ASIC3, the least abundant in the general population, is the most abundant ASIC transcript in colonic neurons.
Transcription (transcript) of ASIC in neurons associated with asic
3) Confidence 0.43 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17177258 Disease Relevance 0 Pain Relevance 0.25
QPCR of laser captured colonic neurons revealed that ASIC3 was the most abundant ASIC transcript, followed by ASIC1, then ASIC2.
Transcription (transcript) of ASIC in neurons associated with asic
4) Confidence 0.43 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17177258 Disease Relevance 0 Pain Relevance 0.36
The hyperalgesia was associated with increased mRNA expression of acid-sensing ion channel (ASIC) 1a, 1b and 3 in the ipsi-lateral dorsal root ganglions (DRGs) by RT-PCR and c-Fos in the ipsi-lateral spinal dorsal horn by immunohistochemistry.
Transcription (expression) of ASIC in dorsal root ganglions associated with ganglion cysts, hyperalgesia, spinal dorsal horn and asic
5) Confidence 0.10 Published 2006 Journal Bone Section Abstract Doc Link 16769263 Disease Relevance 1.70 Pain Relevance 1.01

General Comments

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