INT136192

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Context Info
Confidence 0.35
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.44
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn2) plasma membrane (Accn2)
Anatomy Link Frequency
DRGs 2
Accn2 (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 12 99.90 Very High Very High Very High
spinal dorsal horn 2 98.44 Very High Very High Very High
ASIC 6 93.56 High High
IPN 2 92.80 High High
TRP channel 2 91.08 High High
Pain 12 75.00 Quite High
Inflammation 10 75.00 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 12 99.90 Very High Very High Very High
Ganglion Cysts 6 99.68 Very High Very High Very High
Inflammatory Pain 2 92.80 High High
Hypercalcemia 6 89.64 High High
Osteoporosis 6 89.00 High High
Pain 10 75.00 Quite High
INFLAMMATION 4 75.00 Quite High
Acidosis 4 56.88 Quite High
Bone Cancer 2 46.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, bafilomycin A1, an inhibitor of the vacuolar H+-ATPase, reversed the hyperalgesia and down-regulated ASIC1a mRNA expression in the DRGs.
Negative_regulation (down-regulated) of Gene_expression (expression) of ASIC1a in DRGs associated with ganglion cysts and hyperalgesia
1) Confidence 0.35 Published 2006 Journal Bone Section Abstract Doc Link 16769263 Disease Relevance 0.97 Pain Relevance 0.76
Of note, ZOL decreased the ASIC1a mRNA expression and c-Fos.
Negative_regulation (decreased) of Gene_expression (expression) of ASIC1a
2) Confidence 0.35 Published 2006 Journal Bone Section Abstract Doc Link 16769263 Disease Relevance 1.47 Pain Relevance 0.96

General Comments

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