INT136197

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 0.56
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hnrpd) nucleocytoplasmic transport (Hnrpd) mRNA binding (Hnrpd)
nucleolus (Hnrpd) RNA binding (Hnrpd) nucleus (Hnrpd)
Anatomy Link Frequency
brain 1
Hnrpd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 20 100.00 Very High Very High Very High
cytokine 120 91.04 High High
Neurotransmitter 2 90.28 High High
cva 4 76.08 Quite High
corticosteroid 4 28.64 Quite Low
Inflammation 24 5.00 Very Low Very Low Very Low
isoflurane 20 5.00 Very Low Very Low Very Low
fibrosis 8 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 64 79.20 Quite High
Hemorrhage 4 76.08 Quite High
Toxicity 16 25.72 Quite Low
Graft Vs Host Disease 24 5.00 Very Low Very Low Very Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Fibrosis 8 5.00 Very Low Very Low Very Low
Cancer 8 5.00 Very Low Very Low Very Low
Demyelinating Disease 4 5.00 Very Low Very Low Very Low
Overdose 4 5.00 Very Low Very Low Very Low
Communicable Diseases 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AUF1 is expressed in the developing brain, binds to AT-rich double-stranded DNA, and regulates enkephalin gene expression.
AUF1 Binding (binds) of in brain associated with enkephalin
1) Confidence 0.38 Published 2006 Journal J. Biol. Chem. Section Title Doc Link 16769718 Disease Relevance 0 Pain Relevance 0.72
AUF1 proteins are shown here to provide direct interaction between these upstream AT-rich DNA sequences and the TATA region of the rENK gene.
AUF1 Binding (interaction) of
2) Confidence 0.29 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16769718 Disease Relevance 0 Pain Relevance 0.68
Mechanistically, Pin1 interacts with and controls the ARE mRNA-binding activity of AUF1.
AUF1 Binding (binding) of
3) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.14 Pain Relevance 0.07
When associated with AUF1, ARE mRNAs such as GM-CSF are rapidly catabolized by the exosome preventing translation.
AUF1 Binding (associated) of
4) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.14 Pain Relevance 0.10
Mechanistically, Pin1 interacts with and controls the ARE mRNA-binding activity of AUF1.
AUF1 Binding (activity) of
5) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.14 Pain Relevance 0.07
Cell activation rapidly increased Pin1 activity leading to AUF1 isomerization and loss of mRNA binding.
AUF1 Binding (binding) of
6) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.15 Pain Relevance 0.11

General Comments

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