INT136197

Context Info Confidence 0.38 First Reported 2006 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 6 Disease Relevance 0.56 Pain Relevance 1.76

cytosol (Hnrpd) nucleocytoplasmic transport (Hnrpd) mRNA binding (Hnrpd) nucleolus (Hnrpd) RNA binding (Hnrpd) nucleus (Hnrpd)

Anatomy Link Frequency brain 1 Hnrpd (Rattus norvegicus)

Pain Link Frequency Relevance Heat Enkephalin 20 100.00 cytokine 120 91.04 Neurotransmitter 2 90.28 cva 4 76.08 corticosteroid 4 28.64 Inflammation 24 5.00 isoflurane 20 5.00 fibrosis 8 5.00 chemokine 8 5.00 anesthesia 4 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 64 79.20 Hemorrhage 4 76.08 Toxicity 16 25.72 Graft Vs Host Disease 24 5.00 INFLAMMATION 24 5.00 Fibrosis 8 5.00 Cancer 8 5.00 Demyelinating Disease 4 5.00 Overdose 4 5.00 Communicable Diseases 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

AUF1 is expressed in the developing brain, binds to AT-rich double-stranded DNA, and regulates enkephalin gene expression.

AUF1 Binding (binds) of in brain associated with enkephalin

1) Confidence 0.38 Published 2006 Journal J. Biol. Chem. Section Title Doc Link 16769718 Disease Relevance 0 Pain Relevance 0.72

AUF1 proteins are shown here to provide direct interaction between these upstream AT-rich DNA sequences and the TATA region of the rENK gene.

AUF1 Binding (interaction) of

2) Confidence 0.29 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16769718 Disease Relevance 0 Pain Relevance 0.68

Mechanistically, Pin1 interacts with and controls the ARE mRNA-binding activity of AUF1.

AUF1 Binding (binding) of

3) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.14 Pain Relevance 0.07

When associated with AUF1, ARE mRNAs such as GM-CSF are rapidly catabolized by the exosome preventing translation.

AUF1 Binding (associated) of

4) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.14 Pain Relevance 0.10

Mechanistically, Pin1 interacts with and controls the ARE mRNA-binding activity of AUF1.

AUF1 Binding (activity) of

5) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.14 Pain Relevance 0.07

Cell activation rapidly increased Pin1 activity leading to AUF1 isomerization and loss of mRNA binding.

AUF1 Binding (binding) of

6) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.15 Pain Relevance 0.11

General Comments

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