INT136249

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.18
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Tff3) proteinaceous extracellular matrix (Tff3) endoplasmic reticulum (Drd1a)
plasma membrane (Drd1a) nucleus (Drd1a) intracellular (Drd1a)
Anatomy Link Frequency
NAc 2
Drd1a (Rattus norvegicus)
Tff3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 2 99.88 Very High Very High Very High
Glutamate receptor 1 98.82 Very High Very High Very High
Nucleus accumbens 7 96.52 Very High Very High Very High
Morphine 7 95.36 Very High Very High Very High
addiction 4 94.64 High High
narcan 5 88.88 High High
withdrawal 5 87.12 High High
agonist 2 77.36 Quite High
opiate 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Morphine Dependence 2 95.36 Very High Very High Very High
Substance Withdrawal Syndrome 1 5.00 Very Low Very Low Very Low
Opiate Addiction 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the NAc, the function of the transcription factor cAMP response element binding protein (CREB) and AMPA glutamate receptor subunit, type 1 (GluR1) can be regulated by dopamine (DA) D1 receptor-mediated phosphorylation (P-CREB, P-GluR1).
D1 receptor Positive_regulation (mediated) of Phosphorylation (phosphorylation) of P-GluR1 in NAc associated with nucleus accumbens, dopamine and glutamate receptor
1) Confidence 0.01 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16775132 Disease Relevance 0.18 Pain Relevance 1.23

General Comments

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