INT13626

Context Info Confidence 0.49 First Reported 1983 Last Reported 1996 Negated 0 Speculated 1 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 0.94 Pain Relevance 2.47

lipid binding (Ap2m1) mitochondrion (Ap2m1) vesicle-mediated transport (Ap2m1) plasma membrane (Ap2m1)

Anatomy Link Frequency ileum 1 respiratory 1 Ap2m1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat opioid receptor 14 100.00 Morphine 2 99.20 antagonist 9 99.04 depression 2 98.64 analgesia 5 98.12 Opioid 3 96.72 Delta opioid receptors 1 93.92 Eae 3 93.40 narcan 10 92.32 Antinociceptive 4 82.32

Disease Link Frequency Relevance Heat Respiratory Failure 2 99.12 Catalepsy 3 99.00 Hypertension 2 94.92 Natriuresis 2 90.56 Heart Rate Under Development 1 82.08 Pressure Volume 2 Under Development 1 81.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

D effects involve the activation of mu and k opioid receptors for cardiovascular responses and mu 2 opioid receptors for respiratory depression without any significant effect on delta receptors.

Positive_regulation (activation) of mu 2 in respiratory associated with depression, respiratory failure and opioid receptor

1) Confidence 0.49 Published 1991 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 1675473 Disease Relevance 0.69 Pain Relevance 0.23

The irreversible mu opioid antagonist, beta-funaltrexamine (10 micrograms, i.c.v.: 37%), but not the irreversible mu 1 antagonist, naloxonazine (10 mg/kg, i.v.) inhibited intake, suggesting mu 2 receptor mediation.

Positive_regulation (mediation) of mu 2 associated with antagonist and opioid

2) Confidence 0.49 Published 1990 Journal Brain Res. Section Abstract Doc Link 2155039 Disease Relevance 0 Pain Relevance 0.37

The evidence suggests that the formation of heterologous kappa-delta or mu 1-mu 2 receptor complexes is required for stabilization of the high-affinity conformational state of the receptor.

Positive_regulation (formation) of mu 2

3) Confidence 0.49 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 3005504 Disease Relevance 0 Pain Relevance 0.40

Hence this peptide appears to activate, in addition to delta-receptors, mainly the opioid receptor mu2-subtype, which mediates catalepsy in the rat.

Spec (appears) Positive_regulation (activate) of mu2 associated with catalepsy and opioid receptor

4) Confidence 0.23 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8720471 Disease Relevance 0.24 Pain Relevance 1.15

The findings imply that morphine's actions on the guinea pig ileum were mediated through the mu2 subtype of opioid receptor.

Positive_regulation (mediated) of mu2 in ileum associated with opioid receptor and morphine

5) Confidence 0.13 Published 1983 Journal Neurosci. Lett. Section Abstract Doc Link 6314191 Disease Relevance 0 Pain Relevance 0.33

General Comments

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