INT13626

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Context Info
Confidence 0.49
First Reported 1983
Last Reported 1996
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.94
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ap2m1) mitochondrion (Ap2m1) vesicle-mediated transport (Ap2m1)
plasma membrane (Ap2m1)
Anatomy Link Frequency
ileum 1
respiratory 1
Ap2m1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 14 100.00 Very High Very High Very High
Morphine 2 99.20 Very High Very High Very High
antagonist 9 99.04 Very High Very High Very High
depression 2 98.64 Very High Very High Very High
analgesia 5 98.12 Very High Very High Very High
Opioid 3 96.72 Very High Very High Very High
Delta opioid receptors 1 93.92 High High
Eae 3 93.40 High High
narcan 10 92.32 High High
Antinociceptive 4 82.32 Quite High
Disease Link Frequency Relevance Heat
Respiratory Failure 2 99.12 Very High Very High Very High
Catalepsy 3 99.00 Very High Very High Very High
Hypertension 2 94.92 High High
Natriuresis 2 90.56 High High
Heart Rate Under Development 1 82.08 Quite High
Pressure Volume 2 Under Development 1 81.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
D effects involve the activation of mu and k opioid receptors for cardiovascular responses and mu 2 opioid receptors for respiratory depression without any significant effect on delta receptors.
Positive_regulation (activation) of mu 2 in respiratory associated with depression, respiratory failure and opioid receptor
1) Confidence 0.49 Published 1991 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 1675473 Disease Relevance 0.69 Pain Relevance 0.23
The irreversible mu opioid antagonist, beta-funaltrexamine (10 micrograms, i.c.v.: 37%), but not the irreversible mu 1 antagonist, naloxonazine (10 mg/kg, i.v.) inhibited intake, suggesting mu 2 receptor mediation.
Positive_regulation (mediation) of mu 2 associated with antagonist and opioid
2) Confidence 0.49 Published 1990 Journal Brain Res. Section Abstract Doc Link 2155039 Disease Relevance 0 Pain Relevance 0.37
The evidence suggests that the formation of heterologous kappa-delta or mu 1-mu 2 receptor complexes is required for stabilization of the high-affinity conformational state of the receptor.
Positive_regulation (formation) of mu 2
3) Confidence 0.49 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 3005504 Disease Relevance 0 Pain Relevance 0.40
Hence this peptide appears to activate, in addition to delta-receptors, mainly the opioid receptor mu2-subtype, which mediates catalepsy in the rat.
Spec (appears) Positive_regulation (activate) of mu2 associated with catalepsy and opioid receptor
4) Confidence 0.23 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8720471 Disease Relevance 0.24 Pain Relevance 1.15
The findings imply that morphine's actions on the guinea pig ileum were mediated through the mu2 subtype of opioid receptor.
Positive_regulation (mediated) of mu2 in ileum associated with opioid receptor and morphine
5) Confidence 0.13 Published 1983 Journal Neurosci. Lett. Section Abstract Doc Link 6314191 Disease Relevance 0 Pain Relevance 0.33

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