INT136266

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Context Info
Confidence 0.64
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 8.34
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNQ1) transmembrane transport (KCNQ1)
Anatomy Link Frequency
oocytes 2
myocytes 1
neuronal 1
nerve 1
peripheral neurons 1
KCNQ1 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 55 100.00 Very High Very High Very High
Action potential 162 99.56 Very High Very High Very High
unmyelinated 10 99.48 Very High Very High Very High
Neuropathic pain 8 94.00 High High
antagonist 7 93.20 High High
Dopamine 2 92.00 High High
anesthesia 2 79.12 Quite High
isoflurane 2 78.68 Quite High
Mexiletine 40 72.32 Quite High
gABA 1 67.72 Quite High
Disease Link Frequency Relevance Heat
Syndrome 537 100.00 Very High Very High Very High
Nociception 2 98.52 Very High Very High Very High
Disease 108 97.52 Very High Very High Very High
Neuropathic Pain 8 94.00 High High
Epilepsy 21 93.16 High High
Heart Rate Under Development 105 91.12 High High
Cognitive Disorder 12 90.40 High High
Sudden Death 37 90.08 High High
Cv General 2 Under Development 10 90.00 High High
Channelopathies 10 88.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most prevalent LQTS variant (LQT1) is caused by mutations in the KCNQ1 gene, with approximately half of the genotyped patients carrying KCNQ1 mutations.
Gene_expression (prevalent) of LQT1 associated with syndrome
1) Confidence 0.64 Published 2008 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2474834 Disease Relevance 1.42 Pain Relevance 0.05
The KCNQ1 gene and the KCNE1 gene encode respectively the alpha (KvLQT1) and the ?
Gene_expression (gene) of KCNQ1
2) Confidence 0.64 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2474834 Disease Relevance 1.09 Pain Relevance 0.09
No mutations were identified in KCNQ1 (codes for the ?
Gene_expression (codes) of KCNQ1
3) Confidence 0.60 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2082660 Disease Relevance 0.33 Pain Relevance 0.14
KCNQ1 mutations are found in the LQT1 variant of LQTS which is also its most prevalent form.
Gene_expression (found) of KCNQ1 associated with syndrome
4) Confidence 0.57 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2474834 Disease Relevance 1.09 Pain Relevance 0.09
The data show that Kv7 channels are present on axons of unmyelinated, including nociceptive, peripheral human nerve fibers.
Gene_expression (present) of Kv7 in nerve associated with nociception and unmyelinated
5) Confidence 0.57 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18474382 Disease Relevance 0.22 Pain Relevance 0.36
In addition, the slow component of the delayed rectifier current (IKs) is expressed in cardiac ventricular myocytes and contributes to the AP repolarization phase.
Gene_expression (expressed) of IKs in myocytes associated with action potential
6) Confidence 0.50 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944395 Disease Relevance 0.06 Pain Relevance 0.20
Three main compounds have shown the ability of selectively blocking IKs: the above-mentioned chromanol 293B, benzodiazepines and benzamides (Gerlach 2003).
Neg (blocking) Gene_expression (blocking) of IKs
7) Confidence 0.50 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944395 Disease Relevance 0.27 Pain Relevance 0.07
LQT1, LQT5, JLN1, JLN2: KCNQ1 (causing LQT1 and JLN1) and KCNE1 (causing LQT5 and JLN2) encode respectively for the alpha (KvLQT1) and the beta (MinK) subunits of the potassium channel conducting the IKs current, the slow component of the delayed rectifier current (IK) the major repolarizing current during phase 3 of the cardiac action potential.
Gene_expression (causing) of KCNQ1 associated with action potential and potassium channel
8) Confidence 0.38 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2363724 Disease Relevance 0.62 Pain Relevance 0.12
LQT1, LQT5, JLN1, JLN2: KCNQ1 (causing LQT1 and JLN1) and KCNE1 (causing LQT5 and JLN2) encode respectively for the alpha (KvLQT1) and the beta (MinK) subunits of the potassium channel conducting the IKs current, the slow component of the delayed rectifier current (IK) the major repolarizing current during phase 3 of the cardiac action potential.
Gene_expression (causing) of KCNQ1 associated with action potential and potassium channel
9) Confidence 0.38 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2363724 Disease Relevance 0.62 Pain Relevance 0.12
LQT1, LQT5, JLN1, JLN2: KCNQ1 (causing LQT1 and JLN1) and KCNE1 (causing LQT5 and JLN2) encode respectively for the alpha (KvLQT1) and the beta (MinK) subunits of the potassium channel conducting the IKs current, the slow component of the delayed rectifier current (IK) the major repolarizing current during phase 3 of the cardiac action potential.
Gene_expression (causing) of LQT1 associated with action potential and potassium channel
10) Confidence 0.38 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2363724 Disease Relevance 0.61 Pain Relevance 0.12
The ventricular effective refractory period (VERP) in right ventricular apex and base was significantly longer in LQT2 than LQT1 (P < 0.05) or LMC (P < 0.01), with a greater VERP dispersion in LQT2 than LQT1 rabbits.
Gene_expression (rabbits) of LQT1
11) Confidence 0.34 Published 2010 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 20581090 Disease Relevance 0.19 Pain Relevance 0.18
We investigated the effect of a Bristol-Myers Squibb compound (S)-N-[1-(3-morpholin-4-yl-phenyl)-ethyl]-3-phenyl-acrylamide [(S)-1] on cloned human Kv7.1-5 potassium channels expressed in Xenopus laevis oocytes.
Gene_expression (expressed) of Kv7 in oocytes associated with potassium channel
12) Confidence 0.33 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16904708 Disease Relevance 0.28 Pain Relevance 0.22
Ci KCNQ1 expressed robustly in Xenopus oocytes, generating non-inactivating currents with slow activation and deactivation (Figure 7A).
Gene_expression (expressed) of KCNQ1 in oocytes
13) Confidence 0.31 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2597720 Disease Relevance 0 Pain Relevance 0
In situ hybridization revealed, remarkably, widespread expression of C. intestinalis KCNQ1 in central and peripheral neurons (Figure 6A–C).
Gene_expression (expression) of KCNQ1 in peripheral neurons
14) Confidence 0.31 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2597720 Disease Relevance 0 Pain Relevance 0
In contrast, (S)-1 produced a hyperpolarizing shift of the activation curve for Kv7.2, Kv7.2/Kv7.3, Kv7.4 and Kv7.5.
Gene_expression (produced) of Kv7
15) Confidence 0.29 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16904708 Disease Relevance 0.26 Pain Relevance 0.21
In contrast, (S)-1 produced a hyperpolarizing shift of the activation curve for Kv7.2, Kv7.2/Kv7.3, Kv7.4 and Kv7.5.
Gene_expression (produced) of Kv7
16) Confidence 0.29 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16904708 Disease Relevance 0.26 Pain Relevance 0.21
In contrast, (S)-1 produced a hyperpolarizing shift of the activation curve for Kv7.2, Kv7.2/Kv7.3, Kv7.4 and Kv7.5.
Gene_expression (produced) of Kv7
17) Confidence 0.29 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16904708 Disease Relevance 0.26 Pain Relevance 0.21
In contrast, (S)-1 produced a hyperpolarizing shift of the activation curve for Kv7.2, Kv7.2/Kv7.3, Kv7.4 and Kv7.5.
Gene_expression (produced) of Kv7
18) Confidence 0.29 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16904708 Disease Relevance 0.26 Pain Relevance 0.21
In contrast, (S)-1 produced a hyperpolarizing shift of the activation curve for Kv7.2, Kv7.2/Kv7.3, Kv7.4 and Kv7.5.
Gene_expression (produced) of Kv7
19) Confidence 0.29 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16904708 Disease Relevance 0.26 Pain Relevance 0.21
Invertebrate KCNQ sequences fell into two groups, one with SID sequences like mammalian KCNQ1 (honey bee Apis mellifera KCNQ, Caenorhabditis elegans KQT-3, and C. intestinalis KCNQ1) (Figure 2F, yellow shading) and the other with sequences intermediate between KCNQ1 and the mammalian neuronal KCNQs (e.g., D. melanogaster KCNQ, C. elegans KQT-1, and the beetle Tribolium castaneum KCNQ).
Gene_expression (sequences) of KCNQ in neuronal
20) Confidence 0.24 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2597720 Disease Relevance 0 Pain Relevance 0.03

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