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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 3.28
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNQ1) transmembrane transport (KCNQ1)
Anatomy Link Frequency
neuron 1
KCNQ1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Action potential 8 98.60 Very High Very High Very High
sodium channel 17 90.08 High High
action potential duration 2 85.52 High High
Calcium channel 5 56.56 Quite High
tetrodotoxin 1 50.64 Quite High
gABA 1 47.28 Quite Low
potassium channel 9 25.60 Quite Low
Dopamine 2 25.00 Low Low
antagonist 1 25.00 Low Low
Mexiletine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 295 100.00 Very High Very High Very High
Disease 49 96.56 Very High Very High Very High
Cv General 2 Under Development 3 90.48 High High
Sudden Infant Death Syndrome 38 87.64 High High
Symphalangism 5 85.60 High High
Congenital Anomalies 16 84.64 Quite High
Malignant Neoplastic Disease 11 83.44 Quite High
Myocardial Infarction 12 80.32 Quite High
Heart Rate Under Development 51 79.32 Quite High
Syncope 39 78.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CACNA1c (LQT8) – Timothy syndrome
LQT8 Binding (syndrome) of associated with syndrome
1) Confidence 0.36 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2474834 Disease Relevance 1.14 Pain Relevance 0.15
The most prevalent LQTS variant (LQT1) is caused by mutations in the KCNQ1 gene, with approximately half of the genotyped patients carrying KCNQ1 mutations.
LQT1 Binding (caused) of associated with syndrome
2) Confidence 0.36 Published 2008 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2474834 Disease Relevance 1.41 Pain Relevance 0.05
In the last few years several studies have outlined the distinguishing features of the three most common genetic variants of LQTS (LQT1, LQT2, LQT3), which account for approximately 97% of all genotyped patients.
LQT1 Binding (account) of associated with syndrome
3) Confidence 0.21 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2363724 Disease Relevance 0.73 Pain Relevance 0.03
Homo- and heteromeric complexes of KCNQ channel subunits are the molecular correlate of the M-current, a neuron-specific voltage-dependent K(+) current with a well established role in control of neural excitability.
KCNQ Binding (complexes) of in neuron
4) Confidence 0.10 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16775195 Disease Relevance 0 Pain Relevance 0.05

General Comments

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