INT136268

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Context Info
Confidence 0.75
First Reported 2003
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 22
Total Number 27
Disease Relevance 2.84
Pain Relevance 26.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NAV1) cytoplasm (NAV1)
Anatomy Link Frequency
dorsal root ganglion 9
neck 1
neuronal 1
cleavage 1
head 1
NAV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 1445 100.00 Very High Very High Very High
Nav1.9 174 100.00 Very High Very High Very High
Nav1.1 168 100.00 Very High Very High Very High
nav1.8 146 100.00 Very High Very High Very High
Nav1.7 78 100.00 Very High Very High Very High
Nav1.6 56 100.00 Very High Very High Very High
nav1.3 51 100.00 Very High Very High Very High
Nav1.2 42 100.00 Very High Very High Very High
dorsal root ganglion 20 100.00 Very High Very High Very High
Central nervous system 12 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 21 100.00 Very High Very High Very High
Pain 28 98.04 Very High Very High Very High
Nociception 7 97.00 Very High Very High Very High
Sperm Disorder 75 94.88 High High
Adhesions 6 90.60 High High
Neuroblastoma 18 89.92 High High
Channelopathies 1 82.32 Quite High
Targeted Disruption 12 80.16 Quite High
Epilepsy 3 76.64 Quite High
Neuropathic Pain 13 76.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Low, clinically relevant orphenadrine concentration produces a significant block of Nav1.7, Nav1.8, and Nav1.9 channels, which are critical for experiencing pain sensations, indicating a role for sodium channel blockade in the clinical efficacy of orphenadrine as analgesic compound.
Neg (block) Localization (block) of Nav1 associated with pain, analgesic, sodium channel, nav1.8, nav1.7 and nav1.9
1) Confidence 0.75 Published 2009 Journal Pain Section Abstract Doc Link 19217209 Disease Relevance 0.22 Pain Relevance 1.59
Low, clinically relevant orphenadrine concentration produces a significant block of Nav1.7, Nav1.8, and Nav1.9 channels, which are critical for experiencing pain sensations, indicating a role for sodium channel blockade in the clinical efficacy of orphenadrine as analgesic compound.
Neg (block) Localization (block) of Nav1 associated with pain, analgesic, sodium channel, nav1.8, nav1.7 and nav1.9
2) Confidence 0.75 Published 2009 Journal Pain Section Abstract Doc Link 19217209 Disease Relevance 0.22 Pain Relevance 1.59
Low, clinically relevant orphenadrine concentration produces a significant block of Nav1.7, Nav1.8, and Nav1.9 channels, which are critical for experiencing pain sensations, indicating a role for sodium channel blockade in the clinical efficacy of orphenadrine as analgesic compound.
Neg (block) Localization (block) of Nav1 associated with pain, analgesic, sodium channel, nav1.8, nav1.7 and nav1.9
3) Confidence 0.75 Published 2009 Journal Pain Section Abstract Doc Link 19217209 Disease Relevance 0.22 Pain Relevance 1.59
For example, the channels Nav1.1, Nav1.2, Nav1.3, Nav1.6, and Nav1.7 are predominantly localized in the central and peripheral nervous systems; Nav1.8 and Nav1.9 primarily in the dorsal root ganglion; Nav1.4 primarily at skeletal muscular junctions; Nav1.5 primarily in cardiac tissue (Table 1) [8].
Localization (localized) of Nav1 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, nav1.1, nav1.2, nav1.8, nav1.9, nav1.3, nav1.6 and nav1.7
4) Confidence 0.75 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1988852 Disease Relevance 0.10 Pain Relevance 1.22
For example, the channels Nav1.1, Nav1.2, Nav1.3, Nav1.6, and Nav1.7 are predominantly localized in the central and peripheral nervous systems; Nav1.8 and Nav1.9 primarily in the dorsal root ganglion; Nav1.4 primarily at skeletal muscular junctions; Nav1.5 primarily in cardiac tissue (Table 1) [8].
Localization (localized) of Nav1 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, nav1.1, nav1.2, nav1.8, nav1.9, nav1.3, nav1.6 and nav1.7
5) Confidence 0.75 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1988852 Disease Relevance 0.10 Pain Relevance 1.23
For example, the channels Nav1.1, Nav1.2, Nav1.3, Nav1.6, and Nav1.7 are predominantly localized in the central and peripheral nervous systems; Nav1.8 and Nav1.9 primarily in the dorsal root ganglion; Nav1.4 primarily at skeletal muscular junctions; Nav1.5 primarily in cardiac tissue (Table 1) [8].
Localization (localized) of Nav1 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, nav1.1, nav1.2, nav1.8, nav1.9, nav1.3, nav1.6 and nav1.7
6) Confidence 0.75 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1988852 Disease Relevance 0.10 Pain Relevance 1.23
For example, the channels Nav1.1, Nav1.2, Nav1.3, Nav1.6, and Nav1.7 are predominantly localized in the central and peripheral nervous systems; Nav1.8 and Nav1.9 primarily in the dorsal root ganglion; Nav1.4 primarily at skeletal muscular junctions; Nav1.5 primarily in cardiac tissue (Table 1) [8].
Localization (localized) of Nav1 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, nav1.1, nav1.2, nav1.8, nav1.9, nav1.3, nav1.6 and nav1.7
7) Confidence 0.75 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1988852 Disease Relevance 0.10 Pain Relevance 1.23
Now we use different colors for each channel type, with blue, green, red, cyan, magenta, yellow, black, orange, grey representing Nav1.1, 1.2, 1.3, 1.4, 1.5., 1.6, 1.7, 1.8, 1.9, respectively.
Localization (representing) of Nav1 associated with nav1.1
8) Confidence 0.75 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1988852 Disease Relevance 0 Pain Relevance 0.17
For example, the channels Nav1.1, Nav1.2, Nav1.3, Nav1.6, and Nav1.7 are predominantly localized in the central and peripheral nervous systems; Nav1.8 and Nav1.9 primarily in the dorsal root ganglion; Nav1.4 primarily at skeletal muscular junctions; Nav1.5 primarily in cardiac tissue (Table 1) [8].
Localization (localized) of Nav1 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, nav1.1, nav1.2, nav1.8, nav1.9, nav1.3, nav1.6 and nav1.7
9) Confidence 0.75 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1988852 Disease Relevance 0.10 Pain Relevance 1.22
For example, the channels Nav1.1, Nav1.2, Nav1.3, Nav1.6, and Nav1.7 are predominantly localized in the central and peripheral nervous systems; Nav1.8 and Nav1.9 primarily in the dorsal root ganglion; Nav1.4 primarily at skeletal muscular junctions; Nav1.5 primarily in cardiac tissue (Table 1) [8].
Localization (localized) of Nav1 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, nav1.1, nav1.2, nav1.8, nav1.9, nav1.3, nav1.6 and nav1.7
10) Confidence 0.75 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1988852 Disease Relevance 0.10 Pain Relevance 1.23
In the case of Nav1.7, both the wild type and the splice variant were detected in some sperm samples while only the splice variant was present in other sperm cDNAs (see Fig. 1) The mRNAs of the Nav ?
Localization (case) of Nav1 in sperm associated with nav1.7
11) Confidence 0.73 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.90
SCN2A (Nav1.2) immunostaining was located in the flagellum and over the post-equatorial region of the head.
Localization (located) of Nav1 in flagellum associated with nav1.2
12) Confidence 0.73 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.51
The localization of Nav1.8 in the flagellum and around the neck led us to hypothesize that it could be involved in modulation of flagellar activity and sperm motility.
Localization (localization) of Nav1 in neck associated with sperm disorder and nav1.8
13) Confidence 0.73 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0.36 Pain Relevance 0.89
Experiments were repeated at least three times with identical localization sites for each Nav channel in all cases.
Localization (localization) of Nav
14) Confidence 0.73 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0.06 Pain Relevance 1.03
SCN5A (Nav1.5) staining was strictly localized in the post-equatorial region of the head.
Localization (localized) of Nav1 in head
15) Confidence 0.69 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.45
Generally, Nav1.1 and Nav1.3 are localized to the soma of the neuron, where they may control neuronal excitability through integration of synaptic impulses to set the threshold for action potential initiation and propagation to the dendritic and axonal compartments.
Localization (localized) of Nav1 in soma associated with action potential, nav1.3, neuronal excitability and nav1.1
16) Confidence 0.68 Published 2003 Journal Genome Biol Section Body Doc Link PMC153452 Disease Relevance 0.08 Pain Relevance 1.36
For example, the channels Nav1.1, Nav1.2, Nav1.3, Nav1.6, and Nav1.7 are predominantly localized in the central and peripheral nervous systems; Nav1.8 and Nav1.9 primarily in the dorsal root ganglion; Nav1.4 primarily at skeletal muscular junctions; Nav1.5 primarily in cardiac tissue (Table 1) [8].
Localization (localized) of Nav1 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, nav1.1, nav1.2, nav1.8, nav1.9, nav1.3, nav1.6 and nav1.7
17) Confidence 0.65 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1988852 Disease Relevance 0.10 Pain Relevance 1.27
For example, the channels Nav1.1, Nav1.2, Nav1.3, Nav1.6, and Nav1.7 are predominantly localized in the central and peripheral nervous systems; Nav1.8 and Nav1.9 primarily in the dorsal root ganglion; Nav1.4 primarily at skeletal muscular junctions; Nav1.5 primarily in cardiac tissue (Table 1) [8].
Localization (localized) of Nav1 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, nav1.1, nav1.2, nav1.8, nav1.9, nav1.3, nav1.6 and nav1.7
18) Confidence 0.65 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1988852 Disease Relevance 0.10 Pain Relevance 1.22
For example, the channels Nav1.1, Nav1.2, Nav1.3, Nav1.6, and Nav1.7 are predominantly localized in the central and peripheral nervous systems; Nav1.8 and Nav1.9 primarily in the dorsal root ganglion; Nav1.4 primarily at skeletal muscular junctions; Nav1.5 primarily in cardiac tissue (Table 1) [8].
Localization (localized) of Nav1 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, nav1.1, nav1.2, nav1.8, nav1.9, nav1.3, nav1.6 and nav1.7
19) Confidence 0.65 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1988852 Disease Relevance 0.10 Pain Relevance 1.26
In this study, we explored whether ankyrin-G has a role in modifying gating properties of the neuronal Nav1.6 channel that is predominantly localized at nodes of Ranvier and initial segments.
Localization (localized) of Nav1 in neuronal associated with nav1.6
20) Confidence 0.61 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16775201 Disease Relevance 0 Pain Relevance 0.44

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