INT136269

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Context Info
Confidence 0.61
First Reported 2005
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.27
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCR2) plasma membrane (CCR2) cytoplasm (CCR2)
signal transducer activity (CCR2)
Anatomy Link Frequency
synovium 1
DRG 1
CCR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 142 100.00 Very High Very High Very High
chemokine 60 99.68 Very High Very High Very High
dorsal root ganglion 4 99.12 Very High Very High Very High
Action potential 1 58.88 Quite High
Pain 2 25.00 Low Low
Sciatica 1 25.00 Low Low
nociceptor 1 25.00 Low Low
Inflammation 11 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Rheumatism 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 142 100.00 Very High Very High Very High
Injury 1 99.46 Very High Very High Very High
Ganglion Cysts 5 99.12 Very High Very High Very High
Nociception 3 97.36 Very High Very High Very High
Disease 6 8.88 Low Low
INFLAMMATION 11 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low
Frailty 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study mRNA for other chemokine receptors were detected in the RA synovium, such as CXCR1, CXCR2, CXCR4, Bob, CCR1, CCR2a, CCR7, CCR9 and CX3CR1 (CXCR3 was not on the microarray).
Neg (not) Transcription (detected) of CCR2a in synovium associated with chemokine and rheumatoid arthritis
1) Confidence 0.61 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.45 Pain Relevance 0.47
Previous experimental results from our laboratory demonstrated that monocyte chemoattractant protein-1 (MCP-1) depolarizes or increases the excitability of nociceptive neurons in the intact dorsal root ganglion (DRG) after a chronic compression of the DRG (CCD), an injury that upregulates neuronal expression of both MCP-1 and mRNA for its receptor CCR2.
Transcription (expression) of CCR2 in DRG associated with ganglion cysts, nociception, dorsal root ganglion and injury
2) Confidence 0.12 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16775210 Disease Relevance 0.81 Pain Relevance 0.22

General Comments

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