INT136270

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Context Info
Confidence 0.09
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.82
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCR2) plasma membrane (CCR2) cytoplasm (CCR2)
signal transducer activity (CCR2)
Anatomy Link Frequency
dorsal root ganglion 2
CCR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
dorsal root ganglion 4 99.54 Very High Very High Very High
Action potential 1 58.88 Quite High
Pain 1 25.00 Low Low
Sciatica 1 25.00 Low Low
nociceptor 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Injury 1 99.88 Very High Very High Very High
Ganglion Cysts 5 99.54 Very High Very High Very High
Nociception 3 97.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous experimental results from our laboratory demonstrated that monocyte chemoattractant protein-1 (MCP-1) depolarizes or increases the excitability of nociceptive neurons in the intact dorsal root ganglion (DRG) after a chronic compression of the DRG (CCD), an injury that upregulates neuronal expression of both MCP-1 and mRNA for its receptor CCR2.
Positive_regulation (upregulates) of in dorsal root ganglion Transcription (expression) of CCR2 in DRG associated with ganglion cysts, nociception, dorsal root ganglion and injury
1) Confidence 0.09 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16775210 Disease Relevance 0.82 Pain Relevance 0.22

General Comments

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