INT136273

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.14
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (NGF, BDNF) endosome (NGF) signal transduction (NGF)
extracellular space (NGF) cytoplasmic membrane-bounded vesicle (BDNF)
Anatomy Link Frequency
neurons 2
nociceptors 2
NGF (Homo sapiens)
BDNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 59 100.00 Very High Very High Very High
IPN 2 100.00 Very High Very High Very High
nociceptor 2 98.12 Very High Very High Very High
Lasting pain 1 97.56 Very High Very High Very High
Analgesic 1 95.92 Very High Very High Very High
Inflammation 1 93.24 High High
Central nervous system 1 91.44 High High
Dorsal horn 2 90.36 High High
Pain 19 89.04 High High
cytokine 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 6 100.00 Very High Very High Very High
Inflammatory Pain 2 100.00 Very High Very High Very High
Pain 15 97.56 Very High Very High Very High
INFLAMMATION 1 93.24 High High
Disease 10 37.28 Quite Low
Low Back Pain 5 5.00 Very Low Very Low Very Low
Intervertebral Disk Degeneration 4 5.00 Very Low Very Low Very Low
Osteoarthritis 3 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies by Zhao and colleagues suggest that NGF may regulate inflammatory pain in sensory nociceptive neurons in part through the expression of BDNF [33].
NGF Spec (may) Regulation (regulate) of Gene_expression (expression) of BDNF in neurons associated with nociception, nerve growth factor and ipn
1) Confidence 0.41 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.60 Pain Relevance 0.77
NGF regulates the expression of a second neurotrophin, brain-derived neurotrophic factor (BDNF), in nociceptors.
NGF Regulation (regulates) of Gene_expression (expression) of neurotrophin in nociceptors associated with nerve growth factor and nociceptor
2) Confidence 0.22 Published 2006 Journal Annu. Rev. Neurosci. Section Abstract Doc Link 16776595 Disease Relevance 0.53 Pain Relevance 1.01

General Comments

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