INT136287

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.32
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
heart 2
endothelial cells 1
brain 1
Icam1 (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 13 85.52 High High
Inflammation 7 74.72 Quite High
cINOD 1 57.92 Quite High
COX2 1 25.00 Low Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 35 99.60 Very High Very High Very High
Brain Injury 1 99.56 Very High Very High Very High
Myocardial Infarction 18 86.40 High High
Cv General 3 Under Development 13 85.52 High High
Cardiovascular Disease 9 79.00 Quite High
INFLAMMATION 8 74.72 Quite High
Adhesions 11 61.28 Quite High
Thrombosis 2 61.28 Quite High
Disease Progression 1 57.56 Quite High
Atherosclerosis 8 56.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to get insight into the mechanism of cadmium (Cd)-induced brain injury, we investigated the effects of Cd on the induction of COX-2 and ICAM-1 in bEnd.3 mouse brain endothelial cells (EC).
Spec (investigated) Regulation (effects) of in endothelial cells Spec (investigated) Positive_regulation (induction) of ICAM-1 in brain associated with brain injury
1) Confidence 0.39 Published 2006 Journal Toxicol. Lett. Section Abstract Doc Link 16777358 Disease Relevance 0.22 Pain Relevance 0.06
Circulating sICAM-1 is not influenced by this polymorphism and is not necessarily elevated in acute coronary heart disease.



Neg (not) Regulation (influenced) of Neg (not) Positive_regulation (elevated) of sICAM-1 in heart associated with coronary heart disease
2) Confidence 0.24 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.10 Pain Relevance 0.18

General Comments

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