INT136309

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Context Info
Confidence 0.62
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 12.45
Pain Relevance 5.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl12) plasma membrane (Cxcl12)
Anatomy Link Frequency
bladder 3
HGF 2
myocardium 1
spinal cord 1
bursa 1
Cxcl12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 146 99.28 Very High Very High Very High
Cannabinoid 3 99.20 Very High Very High Very High
Spinal cord 45 99.04 Very High Very High Very High
cytokine 96 99.00 Very High Very High Very High
chemokine 468 98.96 Very High Very High Very High
Central grey 5 98.96 Very High Very High Very High
Inflammation 192 98.80 Very High Very High Very High
Analgesic 6 98.00 Very High Very High Very High
Lasting pain 27 96.16 Very High Very High Very High
anesthesia 11 95.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypersensitivity 30 99.90 Very High Very High Very High
Hypoxia 24 99.36 Very High Very High Very High
Bursitis 18 99.36 Very High Very High Very High
Ganglion Cysts 148 99.28 Very High Very High Very High
Cystitis 85 99.20 Very High Very High Very High
Spinal Cord Injury 57 99.18 Very High Very High Very High
Urological Neuroanatomy 5 98.96 Very High Very High Very High
INFLAMMATION 211 98.80 Very High Very High Very High
Infarction 187 97.00 Very High Very High Very High
Pain 85 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In CYP-induced cystitis, then, activation of CXCR4 receptors, either by its recognized ligand SDF-1 (upregulated as a result of CYP) or due to interaction with MIF (also upregulated as a result of CYP and present in greater quantities than SDF-1) may in fact be contributing to pain hypersensitivity.
Positive_regulation (upregulated) of SDF-1 associated with hypersensitivity, stimulus evoked pain and cystitis
1) Confidence 0.62 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.26 Pain Relevance 0.85
We found c-Kit+ cells increased significantly in the Adv-SDF-1 group than the other group, which were directly mediated by SDF-1/CXCR4.
Positive_regulation (increased) of Adv-SDF-1
2) Confidence 0.43 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.14 Pain Relevance 0
The number of c-Kit+ stem cells, and gene expression of SDF-1, VEGF and bFGF were obviously increased, which was associated with reduced infarct size, thicker left ventricle wall, greater vascular density and cardiocytes density in infarcted hearts of AdV-SDF-1 group.
Positive_regulation (increased) of SDF-1 in hearts
3) Confidence 0.43 Published 2009 Journal Mol Biol Rep Section Abstract Doc Link PMC2831180 Disease Relevance 0.46 Pain Relevance 0
Over-expression SDF-1 in AdV.SDF-1 group increased the expression of VEGF and bFGF mRNA analyzed in the myocardium infarction area (Fig. 4) after MI, and VEGF and bFGF expression increased obviously in 3 day after MI and continued until 7–28 days after MI.Fig. 4SYBR Green real-time PCR analysis of TGF-?
Positive_regulation (group) of AdV.SDF-1 in myocardium associated with infarction and myocardial infarction
4) Confidence 0.43 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.38 Pain Relevance 0
We have previously shown that ddC treatment alone resulted in the upregulation of CXCR4 and SDF1 mostly in glia, but also in some neurons of the DRG.
Positive_regulation (upregulation) of SDF1 in neurons associated with dorsal root ganglion
5) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.85 Pain Relevance 0.48
Our results show that both CXCR4 and SDF-1 are constitutively expressed in normal rat bladder and upregulated during CYP-induced cystitis.
Positive_regulation (upregulated) of SDF-1 in bladder associated with cystitis
6) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.74 Pain Relevance 0.15
ELISA determined MIF and stromal derived factor-1 (SDF-1; cognate ligand for CXCR4) levels.
Positive_regulation (derived) of SDF-1
7) Confidence 0.42 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2588654 Disease Relevance 0.41 Pain Relevance 0.21
Cyclosphosphamide increased bladder SDF-1 levels
Positive_regulation (increased) of SDF-1 in bladder
8) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
We have observed that chemokines expressed by DRG neurons, including MCP1, IP10 and SDF1, can be packaged into secretory vesicles and released upon depolarization [9].
Positive_regulation (packaged) of SDF1 in vesicles associated with chemokine
9) Confidence 0.40 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.28 Pain Relevance 0.55
At the same time, there was increase of the SDF-1 levels in the serum (Fig. 1e).
Positive_regulation (increase) of SDF-1
10) Confidence 0.40 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.78 Pain Relevance 0
Many lumbar DRG non-neuronal cells present in both the naïve (data not shown) and vehicle-treated rats were positive for SDF-1 mRNA transcripts (Additional file 2A, C).
Positive_regulation (positive) of SDF-1 mRNA in neuronal
11) Confidence 0.37 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.51 Pain Relevance 0.09
Cyclophosphamide treatment caused: 1) significant redistribution of CXCR4 immunostaining to all urothelial layers (especially apical surface of superficial cells) and increased bladder CXCR4 expression; 2) increased urine MIF with decreased bladder MIF; 3) increased bladder SDF-1; 4) increased CXCR4-MIF associations.


Positive_regulation (increased) of SDF-1 in bladder
12) Confidence 0.36 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2588654 Disease Relevance 0.40 Pain Relevance 0.16
Also, histology and morphometric measurement showed the expected decrease in infarcted size (IS), and obviously increase in LV wall thickness in AdV.SDF-1 group.
Positive_regulation (increase) of AdV.SDF-1
13) Confidence 0.35 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.06 Pain Relevance 0.07
In our study, VEGF expression level in the AdV-SDF-1 group obviously increased.
Positive_regulation (increased) of AdV-SDF-1
14) Confidence 0.35 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.28 Pain Relevance 0.21
It was previously shown that NRTI treatment alone resulted in both increased mechanical hypersensitivity and upregulation of CXCR4/SDF1 signaling in the DRG [22].
Positive_regulation (upregulation) of SDF1 associated with dorsal root ganglion and hypersensitivity
15) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 1.01 Pain Relevance 0.36
SDF-1 and its receptor CXCR4 are required for stem cells to home to the bone marrow.
Positive_regulation (required) of SDF-1 in bone marrow
16) Confidence 0.23 Published 2007 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570564 Disease Relevance 0.55 Pain Relevance 0.08
This study reports the first in vivo evidence of a functional interaction between chemokine and cannabinoid systems in the brain, showing that the activation of SDF-1alpha/CXCL12 receptors (CXCR4) in the PAG interferes with the analgesic effects of WIN 55212-2.
Positive_regulation (activation) of CXCL12 in brain associated with chemokine, analgesic, cannabinoid and central grey
17) Confidence 0.15 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18281594 Disease Relevance 0.47 Pain Relevance 1.03
The combination of gp120/hCD4 and ddC produced mechanical hypernociception similar to gp120/hCD4 alone, along with enhanced MCP1/CCR2 and SDF1/CXCR4 signaling.
Positive_regulation (enhanced) of SDF1
18) Confidence 0.13 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.54 Pain Relevance 0.31
induced increase in SDF-1expression is a strong chemo-attractant for endothelial progenitor cells [27].
Positive_regulation (increase) of SDF-1expression
19) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806917 Disease Relevance 0.29 Pain Relevance 0.12
We have demonstrated in a previous study that many inflammatory cytokines, including stromal cell-derived factor 1 (SDF-1, CXCL12), are increased in the subacromial bursa [Blaine et al. 2005.
Positive_regulation (increased) of CXCL12 in bursa associated with inflammation and cytokine
20) Confidence 0.09 Published 2006 Journal J. Orthop. Res. Section Abstract Doc Link 16779827 Disease Relevance 0.72 Pain Relevance 0.42

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