INT136310

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.29
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl12) plasma membrane (Cxcl12)
Anatomy Link Frequency
Stromal cell 1
Cxcl12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 8 98.64 Very High Very High Very High
cytokine 15 89.32 High High
fibrosis 6 89.04 High High
chemokine 2 70.96 Quite High
metalloproteinase 8 69.84 Quite High
dexamethasone 3 69.40 Quite High
cINOD 3 66.88 Quite High
COX-2 inhibitor 3 41.36 Quite Low
imagery 45 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bursitis 9 100.00 Very High Very High Very High
INFLAMMATION 8 98.64 Very High Very High Very High
Cancer 148 98.48 Very High Very High Very High
Infarction 62 96.12 Very High Very High Very High
Syndrome 1 92.28 High High
Fibrosis 8 89.04 High High
Myocardial Infarction 100 87.84 High High
Cicatrix 12 75.72 Quite High
Pancreatic Cancer 2 47.92 Quite Low
Necrosis 1 38.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1 down-regulation caused by SDF-1 was associated with decreased collagen accumulation and down-regulated TIMP-1 expression in the infarction area.
Negative_regulation (down-regulation) of SDF-1 associated with infarction
1) Confidence 0.37 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.56 Pain Relevance 0.08
Moreover, infarct size was significantly reduced in AdV-SDF-1 group as compared with the control group (Fig. 7c).
Negative_regulation (reduced) of AdV-SDF-1
2) Confidence 0.32 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.49 Pain Relevance 0
Higher expression levels of VEGF, SDF-1 and HIF-1?
Negative_regulation (levels) of SDF-1
3) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806917 Disease Relevance 1.43 Pain Relevance 0
Stromal cell-derived factor 1 (SDF-1, CXCL12) is increased in subacromial bursitis and downregulated by steroid and nonsteroidal anti-inflammatory agents.
Negative_regulation (downregulated) of CXCL12 in Stromal cell associated with inflammation and bursitis
4) Confidence 0.03 Published 2006 Journal J. Orthop. Res. Section Title Doc Link 16779827 Disease Relevance 0.81 Pain Relevance 0.43

General Comments

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