INT13634

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Context Info
Confidence 0.75
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 11.24
Pain Relevance 2.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CYSLTR1) signal transducer activity (CYSLTR1)
Anatomy Link Frequency
Plasma 1
smooth muscle 1
endothelial cells 1
nasal 1
epithelial cells 1
CYSLTR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 152 100.00 Very High Very High Very High
long-term potentiation 117 100.00 Very High Very High Very High
depression 108 100.00 Very High Very High Very High
aspirin 269 99.36 Very High Very High Very High
antagonist 38 96.72 Very High Very High Very High
Bile 6 94.04 High High
lidocaine 2 88.48 High High
Inflammatory marker 9 85.44 High High
Transcranial magnetic stimulation 12 83.52 Quite High
Potency 5 81.60 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 185 100.00 Very High Very High Very High
Depression 108 100.00 Very High Very High Very High
Nasal Polyps 83 99.74 Very High Very High Very High
Asthma 494 99.52 Very High Very High Very High
Pressure And Volume Under Development 134 99.20 Very High Very High Very High
Chronic Sinusitis 78 98.92 Very High Very High Very High
Eosinophilia 2 98.44 Very High Very High Very High
Edema 4 98.28 Very High Very High Very High
Hypersensitivity 43 97.72 Very High Very High Very High
Disease 82 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, cysLT1 receptors are over expressed and highly responsive to LTE(4), further augmenting the underlying inflammatory disease.
Gene_expression (expressed) of cysLT1 associated with inflammation and disease
1) Confidence 0.75 Published 2003 Journal Clin Rev Allergy Immunol Section Abstract Doc Link 12668897 Disease Relevance 0.70 Pain Relevance 0.31
A functional study using two cell lines, human T lymphocytes (Jurkat) and lung epithelial cells (A549), showed enhanced promoter activity with the ht2 [T-C-G] construct compared to the ht1 [C-A-A] construct, suggesting that this polymorphism modulates CYSLTR1 expression to increase AIA susceptibility.
Gene_expression (expression) of CYSLTR1 in epithelial cells associated with asthma
2) Confidence 0.75 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687575 Disease Relevance 0.65 Pain Relevance 0.03
Leukotriene-related genes and CYSLTR1
Gene_expression (genes) of CYSLTR1
3) Confidence 0.65 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687575 Disease Relevance 1.06 Pain Relevance 0.08
Increased expression of CYSLTR1 with CYLSTR1 and CYSLTR2 polymorphisms are new findings in AIA, while the ALOX5 promoter polymorphism has been noted in AIU.
Gene_expression (expression) of CYSLTR1 associated with asthma and pressure and volume under development
4) Confidence 0.58 Published 2006 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2687575 Disease Relevance 1.80 Pain Relevance 0.17
These results indicate that the bronchoconstriction produced by aerosolized LTD4 in normal subjects is not mediated by cyclooxygenase products of arachidonic acid metabolism or irritant receptors in the upper airways.
Gene_expression (produced) of LTD4 in upper
5) Confidence 0.54 Published 1987 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 3624684 Disease Relevance 0 Pain Relevance 0.15
The expression of BLT and CysLT subtypes on vascular smooth muscle and endothelial cells is highly dependent on transcriptional regulation by pro- and antiinflammatory mediators [22, 33] (see Figure 1).
Gene_expression (expression) of CysLT in endothelial cells associated with inflammation
6) Confidence 0.49 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817543 Disease Relevance 0.10 Pain Relevance 0.12
On the other hand CysLT1 and CysLT2 mRNA levels were similar in CRS and normal mucosa, however significantly higher concentrations of CysLT1 compared to CysLT2 were observed in the CRS-NP group.


Gene_expression (levels) of CysLT1
7) Confidence 0.45 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.30 Pain Relevance 0.08
CysLT1 mRNA expression was significantly increased in CRS-NP compared to CRS and controls, and CRS compared to controls, whereas CysLT2 mRNA was enhanced in both CRS groups without differences between them.
Gene_expression (expression) of CysLT1 mRNA
8) Confidence 0.40 Published 2006 Journal Respir Res Section Abstract Doc Link PMC1481584 Disease Relevance 1.01 Pain Relevance 0.11
Interestingly, the balance of these receptors was similar in healthy and chronic rhinosinusitis subjects, in contrast to the nasal polyp group where expression of CysLT1 was significantly higher when compared to CysLT2.
Gene_expression (expression) of CysLT1 in nasal associated with chronic sinusitis and nasal polyps
9) Confidence 0.40 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.86 Pain Relevance 0.11
Several SNPs in the promoter of LTC4S [19], [45] and ALOX5 [20] that encode key enzymes for CysLT synthesis also showed significant associations with AIA [13], [46].
Gene_expression (synthesis) of CysLT associated with asthma
10) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972220 Disease Relevance 1.29 Pain Relevance 0.15
The CysLT receptors, CysLT1 and CysLT2, are distributed in numerous tissues.
Gene_expression (distributed) of CysLT1
11) Confidence 0.21 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0.61 Pain Relevance 0.03
Eosinophils and mast cells show marked infiltration into the bronchial tree and nasal polyps in AIA and are important cell types in aspirin hypersensitivity of the airways.27,28 Endobronchial aspirin challenge induced a decrease in the number of mast cells that stained for tryptase and an increase in the number of activated eosinophils, which reflects degranulation of these cell types and an early event associated with aspirin-sensitive reactions in AIA subjects.29 Elevated levels of eotaxin and eotaxin-2 expression characterize tissue eosinophilia,30 and these levels are changed after aspirin challenge.31 In addition, both CYSLT1R and CYSLT2R are expressed on eosinophils, especially during exacerbation of asthma.32 Leukotriene receptor antagonists are effective in treating AIA, because they inhibit the production of leukotrienes and the degree of eosinophilic inflammation in the airways.33 Therefore, airway eosinophilia may be a critical marker for responsiveness.
Gene_expression (expressed) of CYSLT1R in eosinophils associated with asthma, aspirin, rhinitis, inflammation, antagonist, hypersensitivity and eosinophilia
12) Confidence 0.20 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2831603 Disease Relevance 1.37 Pain Relevance 0.41
The expression of BLT and CysLT subtypes on vascular smooth muscle and endothelial cells is highly dependent on transcriptional regulation by pro- and antiinflammatory mediators [22, 33] (see Figure 1).
Gene_expression (expression) of CysLT in smooth muscle associated with inflammation
13) Confidence 0.17 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817543 Disease Relevance 0.10 Pain Relevance 0.12
Although over-production of pro-inflammatory cysLTs such as LTC4, LTD4 and LTE4 has been considered as a main cause of aspirin hypersensitivity in asthma [25], recent studies have suggested that other genes may be related to AIA [21,26,27].
Gene_expression (production) of LTD4 associated with asthma, aspirin, inflammation and hypersensitivity
14) Confidence 0.11 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2954844 Disease Relevance 0.89 Pain Relevance 0.23
HFS, that precedes the electrically evoked R2 response to produce LTD-like plasticity, has so far only been applied by Mao and Evinger in five healthy subjects.
Gene_expression (produce) of LTD associated with depression
15) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964285 Disease Relevance 0.10 Pain Relevance 0.16
The HFS LTP-LTD and HFS LTP-LTP protocols showed no significant changes in % inhibition (Fig. 4h,i).
Gene_expression (protocols) of LTD associated with depression and long-term potentiation
16) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964285 Disease Relevance 0.22 Pain Relevance 0.26
HFS was given at the onset of the electrically evoked R2 response to induce LTP-like effects (Fig. 3C), while HFS preceded the electrically evoked R2 response by 5 ms to produce LTD-like plasticity (Fig. 3D).
Gene_expression (produce) of LTD associated with depression and long-term potentiation
17) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964285 Disease Relevance 0.18 Pain Relevance 0.14
Specific changes in ASM cells relevant to GPCR signaling that are known to occur in culture include a rapid and progressive decrease in the expression of Gq-coupled receptors such as the m3 muscarinic acetylcholine receptor (m3 mAChR) [21] and the cysteinyl leukotriene type 1 receptor (CLT1R; Stuart Hirst, personal communication).
Gene_expression (expression) of cysteinyl leukotriene type 1 receptor
18) Confidence 0.05 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0 Pain Relevance 0.03
Plasma incubation of [3H]-LTC4 revealed heat-sensitive dipeptidase and glutamyl transpeptidase activity with significant production of [3H]-LTD4 and [3H]-LTE4 after 5- and 30-min incubation.
Gene_expression (production) of LTD4 in Plasma
19) Confidence 0.01 Published 1991 Journal Circ. Shock Section Abstract Doc Link 1675594 Disease Relevance 0 Pain Relevance 0.20

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