INT136363

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Context Info
Confidence 0.32
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.46
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) aging (Ccl2) extracellular region (Ccl2)
cytoskeleton organization (Ccl2) cytoplasm (Ccl2)
Ccl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 3 86.80 High High
cytokine 13 81.76 Quite High
Inflammatory marker 23 79.52 Quite High
chemokine 4 78.96 Quite High
Inflammation 45 75.00 Quite High
alcohol 1 69.88 Quite High
Paracetamol 1 68.20 Quite High
Inflammatory response 2 61.32 Quite High
tolerance 13 27.68 Quite Low
Angina 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperoxia 49 99.04 Very High Very High Very High
INFLAMMATION 69 86.40 High High
Hepatotoxicity 1 66.16 Quite High
Diabetes Mellitus 24 54.88 Quite High
Myocardial Infarction 8 52.84 Quite High
Toxicity 3 50.00 Quite Low
Pneumonia 5 37.04 Quite Low
Impaired Glucose Tolerance 12 27.68 Quite Low
Diabetic Angiopathy 1 19.92 Low Low
Weight Gain 12 8.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, searching for novel biomarkers that may associate with abnormal glucose regulation, we found that high levels of CRP and MCP-1 measured early after an acute STEMI were associated with abnormal glucose regulation diagnosed in a stable cituation.
Negative_regulation (measured) of Positive_regulation (levels) of MCP-1
1) Confidence 0.32 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940874 Disease Relevance 0.44 Pain Relevance 0.14
APAP also attenuated LPS-induced increases in IL-10 and MCP-1.
Negative_regulation (attenuated) of Positive_regulation (increases) of MCP-1
2) Confidence 0.11 Published 2006 Journal Toxicol In Vitro Section Abstract Doc Link 16782301 Disease Relevance 0.37 Pain Relevance 0.25
By contrast, it prevented the increase of MCP-1 and OPN proteins under hyperoxia (p<0.01 between groups O2-diluent and O2-rolipram for both).
Negative_regulation (prevented) of Positive_regulation (increase) of MCP-1 associated with hyperoxia
3) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2563688 Disease Relevance 0.65 Pain Relevance 0.24

General Comments

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