INT136387

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Context Info
Confidence 0.64
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 7.92
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl5)
Anatomy Link Frequency
leukocytes 1
cerebrospinal fluid 1
neutrophil 1
T cell 1
Cxcl5 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 150 100.00 Very High Very High Very High
chemokine 61 100.00 Very High Very High Very High
Inflammation 138 96.04 Very High Very High Very High
Inflammatory response 33 91.60 High High
fibrosis 13 69.12 Quite High
Inflammatory mediators 12 43.68 Quite Low
headache 1 43.44 Quite Low
Glutamate 2 40.08 Quite Low
member 8 1 23.92 Low Low
Crohn's disease 1 6.36 Low Low
Disease Link Frequency Relevance Heat
Injury 208 98.80 Very High Very High Very High
Stroke 9 98.80 Very High Very High Very High
Targeted Disruption 39 98.60 Very High Very High Very High
Adhesions 5 97.88 Very High Very High Very High
Disease Progression 1 96.88 Very High Very High Very High
INFLAMMATION 183 96.04 Very High Very High Very High
Mycobacterial Infection 145 94.68 High High
Diabetes Mellitus 156 94.32 High High
Infection 116 91.20 High High
Disease 24 89.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The level of chemokine CXCL5 in the cerebrospinal fluid is increased during the first 24 hours of ischaemic stroke and correlates with the size of early brain damage.
Positive_regulation (increased) of CXCL5 in cerebrospinal fluid associated with chemokine and stroke
1) Confidence 0.64 Published 2006 Journal Folia Morphol. (Warsz) Section Title Doc Link 16783727 Disease Relevance 0.57 Pain Relevance 0.25
(CXCL2), PF4 (CXCL4), and ENA-78 (CXCL5) was significantly increased at days 1 and 3 post thermal injury.
Positive_regulation (increased) of CXCL5 associated with injury
2) Confidence 0.41 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2889944 Disease Relevance 1.69 Pain Relevance 0.32
(CXCL2), PF4 (CXCL4), and ENA-78 (CXCL5) was significantly increased at days 1 and 3 post thermal injury.
Positive_regulation (increased) of ENA-78 associated with injury
3) Confidence 0.41 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2889944 Disease Relevance 1.70 Pain Relevance 0.32
Specifically, the high up-regulation of several chemokines (CXCL2, CCL5, CXCL5, CXCL9, CXCL1 CXCL10) which control the recruitment of leukocytes to the vaccination site is important for the early phases of the immune response [45].
Positive_regulation (regulation) of CXCL5 in leukocytes associated with chemokine
4) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748717 Disease Relevance 0.25 Pain Relevance 0.18
Interestingly, both CXCL1 and CXCL5 are induced in response to IL-1?
Positive_regulation (induced) of CXCL5
5) Confidence 0.26 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.10 Pain Relevance 0.07
cells, followed by an increase in transcripts of chemokine genes (cxcl1, cxcl5, and ccl7) and of other genes typical of the myelo-monocytic lineages during disease progression [111].
Positive_regulation (increase) of cxcl5 associated with chemokine and disease progression
6) Confidence 0.25 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 1.06 Pain Relevance 0.25
, epithelial cell-derived neutrophil-activating protein 78 (ENA-78), transforming growth factor ?
Positive_regulation (derived) of ENA-78 in neutrophil
7) Confidence 0.08 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.52 Pain Relevance 0.17
Splenocytes from KO mice activated with anti-CD3 plus anti-CD28, which normally triggers cytokine mRNA stabilization and accumulation [4], [13], showed significantly less IFN-?
Positive_regulation (stabilization) of cytokine mRNA associated with targeted disruption and cytokine
8) Confidence 0.00 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.50 Pain Relevance 0.20
Therefore, Pin1 is necessary for ARE mediated cytokine mRNA stabilization after T cell co-stimulation.
Positive_regulation (stabilization) of cytokine mRNA in T cell associated with cytokine
9) Confidence 0.00 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.53 Pain Relevance 0.15

General Comments

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