INT136388

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 25
Disease Relevance 21.45
Pain Relevance 2.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl5)
Anatomy Link Frequency
brain 2
lung 2
macrophages 1
CSF 1
epithelial cells 1
Cxcl5 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 216 100.00 Very High Very High Very High
chemokine 166 100.00 Very High Very High Very High
Inflammation 296 99.88 Very High Very High Very High
headache 4 97.76 Very High Very High Very High
Inflammatory response 59 57.04 Quite High
fibrosis 59 57.00 Quite High
metalloproteinase 59 46.40 Quite Low
Inflammatory mediators 6 20.32 Low Low
rheumatoid arthritis 88 5.00 Very Low Very Low Very Low
Multiple sclerosis 49 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 313 99.88 Very High Very High Very High
Stroke 36 99.84 Very High Very High Very High
Cancer 830 99.68 Very High Very High Very High
Infection 64 98.66 Very High Very High Very High
Stomach Cancer 754 98.64 Very High Very High Very High
Respiratory Syncytial Virus 104 98.04 Very High Very High Very High
Headache 4 97.76 Very High Very High Very High
Metastasis 91 97.64 Very High Very High Very High
Systemic Sclerosis 34 96.64 Very High Very High Very High
Influenza Virus Infection 88 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, CXCL1, CXCL5/ENA78, CXCL8/IL8, CXCL9/MIG, CXCL10/IP10) were found to be overexpressed in the tumours while CCL15/MIP-1?
Gene_expression (overexpressed) of ENA78 associated with cancer
1) Confidence 0.75 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.30 Pain Relevance 0.05
, CXCL5/ENA78 and IL8 mRNAs' were overexpressed in paired normals, as well.
Gene_expression (overexpressed) of ENA78
2) Confidence 0.65 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.26 Pain Relevance 0.05
Park et al., (2007) [37] had reported CXCL5/ENA78 overexpression to be associated with late stage gastric cancer and nodal metastasis, using immunohistochemistry (IHC).
Gene_expression (overexpression) of ENA78 associated with metastasis and stomach cancer
3) Confidence 0.65 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.08 Pain Relevance 0.04
In accordance, CD14KO mice displayed lower BALF concentrations of LIX, a chemokine exclusively produced by respiratory epithelial cells [20], upon intranasal instillation of R-LPS at low doses.
Gene_expression (produced) of LIX in epithelial cells associated with chemokine
4) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.12 Pain Relevance 0.20
The following genes (CXCL5/ENA-78, CXCL8/IL8, CXCL10/IP10, CXCL9/MIG, CCL3/MIP-1?
Gene_expression (/) of ENA-78
5) Confidence 0.65 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 0.39 Pain Relevance 0
CFD/Adipsin median levels were found to be lower in tumours compared to the levels in PN and AN (p = 0.0324), while CXCL5/ENA78, CCL20/MIP-3?
Gene_expression (/) of ENA78 associated with cancer
6) Confidence 0.65 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.10 Pain Relevance 0.09
, CXCL5/ENA78 and IL8 mRNAs' were overexpressed in paired normals, as well.
Gene_expression (/) of ENA78
7) Confidence 0.65 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.25 Pain Relevance 0.05
CFD/Adipsin median levels were found to be lower in tumours compared to the levels in PN and AN (p = 0.0324), while CXCL5/ENA78, CCL20/MIP-3?
Gene_expression (/) of ENA78 associated with cancer
8) Confidence 0.65 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.10 Pain Relevance 0.09
CXCL5 is one of the ELR-expressing CXC chemokines and is a potent neutrophil attractant and activator.
Gene_expression (expressing) of CXCL5 in neutrophil associated with chemokine
9) Confidence 0.62 Published 2006 Journal Folia Morphol. (Warsz) Section Abstract Doc Link 16783727 Disease Relevance 0.71 Pain Relevance 0.31
CSF CXCL5 levels in stroke patients were significantly higher in comparison with the control group (38.2 +/- 18.4 pg/ml vs. 18.7 +/- 8.2 pg/ml; p < 0.001).
Gene_expression (levels) of CXCL5 in CSF associated with stroke
10) Confidence 0.62 Published 2006 Journal Folia Morphol. (Warsz) Section Abstract Doc Link 16783727 Disease Relevance 0.73 Pain Relevance 0.30
Thus, WT, TLR4KO, MyD88KO and TRIFmut mice were treated with 10 µg of S-LPS or R-LPS and the influx of polymorphonuclear cells (PMNs) into BALF, as well as the BALF concentrations of TNF (a cytokine primarily produced by macrophages)[19], [20] and LIX (a chemokine exclusively produced by respiratory epithelial cells)[20] was measured as read outs for the pulmonary response to local LPS instillation.
Gene_expression (produced) of LIX in macrophages associated with chemokine and cytokine
11) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.35 Pain Relevance 0.32
The objective of the study was to detect CXCL5 levels in the cerebrospinal fluid (CSF) and sera of stroke patients and to investigate the relation between these levels and the volume of brain computed tomography (CT) hypodense areas representing early ischaemic lesions.
Gene_expression (levels) of CXCL5 in brain associated with stroke
12) Confidence 0.55 Published 2006 Journal Folia Morphol. (Warsz) Section Abstract Doc Link 16783727 Disease Relevance 0.73 Pain Relevance 0.31
The objective of the study was to detect CXCL5 levels in the cerebrospinal fluid (CSF) and sera of stroke patients and to investigate the relation between these levels and the volume of brain computed tomography (CT) hypodense areas representing early ischaemic lesions.
Gene_expression (detect) of CXCL5 in brain associated with stroke
13) Confidence 0.55 Published 2006 Journal Folia Morphol. (Warsz) Section Abstract Doc Link 16783727 Disease Relevance 0.73 Pain Relevance 0.31
Relative expression of target mRNAs (Adiponectin Mm00456425_m1, Arg1 Mm00475988_m1, Bcl2 Mm00477631_m1, Bax Mm00432050_m1, Ccl2 Mm00441242_m1, Ccl3 Mm00441258, Ccl5 Mm01302428_m1, Cxcl5 Mm00436451_g1, CD11c Mm00498698_m1, CD3 Mm00442746_m1, CD34 Mm00519283_m1, CD4 Mm00442754_m1, CD8 Mm01182108_m1, F4/80 Mm00802530_m1, G6pase Mm839363_m1, Gr-1 Mm00459644_m1, Il1?
Gene_expression (expression) of Cxcl5 in F4/80
14) Confidence 0.42 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.26 Pain Relevance 0
The low expressed genes included SMAD1, IL-15, CXCL5.
Gene_expression (expressed) of CXCL5
15) Confidence 0.28 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 0.94 Pain Relevance 0.05
, CXCL1, CXCL5/ENA78, CXCL8/IL8, CXCL9/MIG, CXCL10/IP10) were found to be overexpressed in the tumours while CCL15/MIP-1?
Gene_expression (/) of CXCL5 associated with cancer
16) Confidence 0.17 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.28 Pain Relevance 0.05
, CXCL5/ENA78 and IL8 mRNAs' were overexpressed in paired normals, as well.
Gene_expression (overexpressed) of CXCL5
17) Confidence 0.17 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.26 Pain Relevance 0.05
The following genes (CXCL5/ENA-78, CXCL8/IL8, CXCL10/IP10, CXCL9/MIG, CCL3/MIP-1?
Gene_expression (/) of CXCL5
18) Confidence 0.17 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 0.39 Pain Relevance 0
CFD/Adipsin median levels were found to be lower in tumours compared to the levels in PN and AN (p = 0.0324), while CXCL5/ENA78, CCL20/MIP-3?
Gene_expression (/) of CXCL5 associated with cancer
19) Confidence 0.17 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.10 Pain Relevance 0.09
Park et al., (2007) [37] had reported CXCL5/ENA78 overexpression to be associated with late stage gastric cancer and nodal metastasis, using immunohistochemistry (IHC).
Gene_expression (overexpression) of CXCL5 associated with metastasis and stomach cancer
20) Confidence 0.17 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.08 Pain Relevance 0.04

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