INT136414

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Context Info
Confidence 0.26
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.28
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (NMU) extracellular region (NMU) response to stress (NMU)
Anatomy Link Frequency
NMU 1
body 1
NMU (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 1 98.08 Very High Very High Very High
Neuropeptide 2 95.04 Very High Very High Very High
Opioid 1 93.16 High High
Serotonin 1 88.24 High High
monoamine 1 87.16 High High
Cannabinoid 1 82.40 Quite High
headache 2 72.16 Quite High
cva 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 4 100.00 Very High Very High Very High
Arachnoid Cysts 51 98.40 Very High Very High Very High
Chromosome Duplication 1 87.08 High High
Cyst 11 81.08 Quite High
Dizziness 2 72.60 Quite High
Headache 2 72.16 Quite High
Neurological Disease 1 71.32 Quite High
Campomelic Dysplasia 4 5.00 Very Low Very Low Very Low
Meningioma 3 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this overview, an introduction to the GPCRs and the field of central regulation of food intake is provided together with brief mentioning of some other GPCRs that are also implicated in regulation of body weight, such as the melanin-concentrating hormone (MCH), neuromedin U, prolactin-releasing peptide (PrRP), bombesin, cholecystokinin (CCK), Glucagon-like peptide-1 (GLP-1) (and oxyntomodulin), neuropeptide B (NPB) and neuropeptide W (NPW), opioids peptides, free fatty acid (FFA) receptors (GPR40, GPR41).
Regulation (regulation) of neuromedin U in body associated with body weight, neuropeptide, opioid and cholecystokinin
1) Confidence 0.26 Published 2006 Journal CNS Neurol Disord Drug Targets Section Abstract Doc Link 16787226 Disease Relevance 0.32 Pain Relevance 0.37
Only nine genes differed in expression between the two tissues: ASGR1, DPEP2, SOX9, SHROOM3, A2BP1, ATP10D, TRIML1, NMU were down regulated, whereas BEND5 was up regulated in the AC samples.
Regulation (regulated) of NMU in NMU associated with arachnoid cysts
2) Confidence 0.06 Published 2010 Journal Cerebrospinal Fluid Res Section Abstract Doc Link PMC2841093 Disease Relevance 0.96 Pain Relevance 0.07

General Comments

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