INT136414

Context Info Confidence 0.26 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 1.28 Pain Relevance 0.44

signal transduction (NMU) extracellular region (NMU) response to stress (NMU)

Anatomy Link Frequency NMU 1 body 1 NMU (Homo sapiens)

Pain Link Frequency Relevance Heat Cholecystokinin 1 98.08 Neuropeptide 2 95.04 Opioid 1 93.16 Serotonin 1 88.24 monoamine 1 87.16 Cannabinoid 1 82.40 headache 2 72.16 cva 2 5.00 Central nervous system 1 5.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Body Weight 4 100.00 Arachnoid Cysts 51 98.40 Chromosome Duplication 1 87.08 Cyst 11 81.08 Dizziness 2 72.60 Headache 2 72.16 Neurological Disease 1 71.32 Campomelic Dysplasia 4 5.00 Meningioma 3 5.00 Cancer 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In this overview, an introduction to the GPCRs and the field of central regulation of food intake is provided together with brief mentioning of some other GPCRs that are also implicated in regulation of body weight, such as the melanin-concentrating hormone (MCH), neuromedin U, prolactin-releasing peptide (PrRP), bombesin, cholecystokinin (CCK), Glucagon-like peptide-1 (GLP-1) (and oxyntomodulin), neuropeptide B (NPB) and neuropeptide W (NPW), opioids peptides, free fatty acid (FFA) receptors (GPR40, GPR41).

Regulation (regulation) of neuromedin U in body associated with body weight, neuropeptide, opioid and cholecystokinin

1) Confidence 0.26 Published 2006 Journal CNS Neurol Disord Drug Targets Section Abstract Doc Link 16787226 Disease Relevance 0.32 Pain Relevance 0.37

Only nine genes differed in expression between the two tissues: ASGR1, DPEP2, SOX9, SHROOM3, A2BP1, ATP10D, TRIML1, NMU were down regulated, whereas BEND5 was up regulated in the AC samples.

Regulation (regulated) of NMU in NMU associated with arachnoid cysts

2) Confidence 0.06 Published 2010 Journal Cerebrospinal Fluid Res Section Abstract Doc Link PMC2841093 Disease Relevance 0.96 Pain Relevance 0.07

General Comments

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