INT136424

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.48
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (DUSP1) nucleus (DUSP1) cell cycle (DUSP1)
Anatomy Link Frequency
endothelium 2
medial 1
kidney 1
DUSP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 66 100.00 Very High Very High Very High
cytokine 14 100.00 Very High Very High Very High
COX2 1 99.52 Very High Very High Very High
dexamethasone 21 99.50 Very High Very High Very High
alcohol 10 99.28 Very High Very High Very High
withdrawal 1 98.80 Very High Very High Very High
chemokine 3 97.12 Very High Very High Very High
Nucleus accumbens 1 95.52 Very High Very High Very High
opiate 1 69.36 Quite High
cINOD 3 67.36 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 80 100.00 Very High Very High Very High
Stress 22 100.00 Very High Very High Very High
Acute-phase Reaction 1 97.12 Very High Very High Very High
Urological Neuroanatomy 1 96.52 Very High Very High Very High
Cancer 82 95.32 Very High Very High Very High
Disease 25 93.88 High High
Metastasis 61 93.76 High High
Pancreatic Cancer 8 91.72 High High
Malignant Neoplastic Disease 8 90.36 High High
Prostate Cancer 55 89.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Re-exposure to the cue after 3 weeks of withdrawal reinstated heroin-seeking behaviour, which resulted in IEG expression of ania-3, MKP-1, c-fos and Nr4a3 in the medial prefrontal cortex (mPFC), and of ania-3 in the orbital frontal cortex (OFC) and nucleus accumbens core (NAC).
Gene_expression (expression) of MKP-1 in medial associated with nucleus accumbens, urological neuroanatomy and withdrawal
1) Confidence 0.67 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16787418 Disease Relevance 0.23 Pain Relevance 0.17
Importantly, Dex is able to increase the expression of MKP-1, which causes an inactivation of TNF-alpha-induced p38 MAPK and mediates inhibition of E-selectin expression.
Gene_expression (expression) of MKP-1 associated with dexamethasone
2) Confidence 0.67 Published 2007 Journal FASEB J. Section Abstract Doc Link 17099067 Disease Relevance 0.47 Pain Relevance 0.52
Additionally, DUSP1 (dual specificity phosphatase 1) is involved in cell cycle regulation and is known to modulate cytokine expression [17,18].
Gene_expression (expression) of DUSP1 associated with cytokine
3) Confidence 0.62 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC2082467 Disease Relevance 0.27 Pain Relevance 0.33
Thus, our findings introduce MKP-1 as a novel and crucial mediator of the anti-inflammatory action of glucocorticoids at low concentrations in the human endothelium and highlight MKP-1 as an important and promising anti-inflammatory drug target.
Gene_expression (introduce) of MKP-1 in endothelium associated with inflammation
4) Confidence 0.58 Published 2007 Journal FASEB J. Section Abstract Doc Link 17099067 Disease Relevance 0.54 Pain Relevance 0.50
Thus, our findings introduce MKP-1 as a novel and crucial mediator of the anti-inflammatory action of glucocorticoids at low concentrations in the human endothelium and highlight MKP-1 as an important and promising anti-inflammatory drug target.
Gene_expression (introduce) of MKP-1 in endothelium associated with inflammation
5) Confidence 0.58 Published 2007 Journal FASEB J. Section Abstract Doc Link 17099067 Disease Relevance 0.53 Pain Relevance 0.50
The regulated genes include DUSP1, DUSP2, DUSP8, MAP3K8, MAP4K4, FGF13, FGFR2 and FOS.
Gene_expression (include) of DUSP1
6) Confidence 0.46 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 0.49 Pain Relevance 0
The evidence for anti-inflammatory (anti-complement) and pro-inflammatory (COX2, HDACs, IL8, IL1, TNF, DUSP1, DUSP10, AREG) effects in HEK293 cells is the first evidence at the gene expression level for a dual capacity of PAR2 in regulating inflammatory pathways that may have important implications in the kidney and possibly in kidney-related disease.
Gene_expression (expression) of DUSP1 in kidney associated with inflammation, cox2 and disease
7) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 1.08 Pain Relevance 0.28
In contrast to past alcohol consumption, present alcohol intake appears associated with the expression of immediate response genes to tissue damage, repair and remodeling, inflammatory and stress response (IFITM1, CRHBP, TIMP 2 and 3, DUSP1, CTGF).


Gene_expression (expression) of DUSP1 associated with stress, inflammation and alcohol
8) Confidence 0.13 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1774576 Disease Relevance 0.79 Pain Relevance 0.26
Interestingly, this was observed for genes that are activated by glucocorticoids (MKP-1, myocilin, fibronectin) and for genes that are repressed in response to glucocorticoids (TNF?
Gene_expression (fibronectin) of MKP-1
9) Confidence 0.05 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.07 Pain Relevance 0.09

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