INT13643

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.82
First Reported 1985
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 20
Total Number 24
Disease Relevance 1.90
Pain Relevance 20.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) nucleus (Th)
response to stress (Th) cytoplasm (Th)
Anatomy Link Frequency
ventricle 3
nucleus 2
4th ventricle 1
brain 1
NAc 1
Th (Rattus norvegicus)
Th - S40Y (2)
Pain Link Frequency Relevance Heat
narcan 60 100.00 Very High Very High Very High
addiction 18 99.92 Very High Very High Very High
Morphine 201 99.68 Very High Very High Very High
withdrawal 131 99.64 Very High Very High Very High
noradrenaline 15 99.56 Very High Very High Very High
cocaine 14 99.48 Very High Very High Very High
Ventral tegmentum 6 99.44 Very High Very High Very High
Catecholamine 3 99.42 Very High Very High Very High
Nucleus accumbens 6 98.56 Very High Very High Very High
opiate 2 93.04 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 12 98.96 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 12 94.72 High High
Stress 2 87.28 High High
Opiate Addiction 1 77.16 Quite High
Drug Dependence 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tyrosine hydroxylase phosphorylation after naloxone-induced morphine withdrawal in the left ventricle.
Phosphorylation (phosphorylation) of Tyrosine hydroxylase in ventricle associated with narcan, withdrawal and morphine
1) Confidence 0.82 Published 2009 Journal Basic Res. Cardiol. Section Title Doc Link 19104749 Disease Relevance 0.09 Pain Relevance 1.09
When HA-1004 (40 nmol/day), inhibitor of cyclic AMP dependent protein kinase (PKA) was infused, concomitantly with morphine, it diminished the increase in noradrenaline (NA) turnover, total TH expression (95.76 +/- 4.1 %, P < 0.01) and TH phosphorylation at Ser40 (85.5 +/- 11%, P < 0.01) in morphine-withdrawn rats.
Phosphorylation (phosphorylation) of TH associated with noradrenaline and morphine
2) Confidence 0.82 Published 2009 Journal Basic Res. Cardiol. Section Abstract Doc Link 19104749 Disease Relevance 0.06 Pain Relevance 1.22
The purpose of the present study was to evaluate the effects of morphine withdrawal on site-specific tyrosine hydroxylase (TH) phosphorylation in the rat left ventricle.
Phosphorylation (phosphorylation) of TH in ventricle associated with withdrawal and morphine
3) Confidence 0.82 Published 2009 Journal Basic Res. Cardiol. Section Abstract Doc Link 19104749 Disease Relevance 0.09 Pain Relevance 0.96
The purpose of the present study was to evaluate the effects of morphine withdrawal on site-specific tyrosine hydroxylase (TH) phosphorylation in the rat left ventricle.
Phosphorylation (phosphorylation) of tyrosine hydroxylase in ventricle associated with withdrawal and morphine
4) Confidence 0.82 Published 2009 Journal Basic Res. Cardiol. Section Abstract Doc Link 19104749 Disease Relevance 0.09 Pain Relevance 0.96
TH phosphorylation was determined by quantitative blot immunolabelling using phosphorylation state-specific antibodies.
Phosphorylation (phosphorylation) of TH
5) Confidence 0.82 Published 2009 Journal Basic Res. Cardiol. Section Abstract Doc Link 19104749 Disease Relevance 0.08 Pain Relevance 1.03
Low-Na+ medium increases the activity and the phosphorylation of tyrosine hydroxylase in the superior cervical ganglion of the rat.
Phosphorylation (phosphorylation) of tyrosine hydroxylase in superior cervical ganglion associated with ganglion cysts
6) Confidence 0.66 Published 1985 Journal J. Neurochem. Section Title Doc Link 2857766 Disease Relevance 0.34 Pain Relevance 0.14
Low-Na+ medium also increased the incorporation of 32Pi into tyrosine hydroxylase; the dependence of tyrosine hydroxylase phosphorylation on the Na+ concentration resembled that of DOPA synthesis.
Phosphorylation (phosphorylation) of tyrosine hydroxylase associated with addiction
7) Confidence 0.66 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 2857766 Disease Relevance 0.25 Pain Relevance 0.16
These data support the hypothesis that low-Na+ medium stimulates DOPA synthesis by raising intracellular Ca2+, which then promotes the phosphorylation of tyrosine hydroxylase.
Phosphorylation (phosphorylation) of tyrosine hydroxylase
8) Confidence 0.66 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 2857766 Disease Relevance 0.22 Pain Relevance 0.15
When HA-1004 (40 nmol/day), inhibitor of cyclic AMP dependent protein kinase (PKA) was infused, concomitantly with morphine, it diminished the increase in noradrenaline (NA) turnover, total TH expression (95.76 +/- 4.1 %, P < 0.01) and TH phosphorylation at Ser40 (85.5 +/- 11%, P < 0.01) in morphine-withdrawn rats.
Phosphorylation (phosphorylation) of TH associated with noradrenaline and morphine
9) Confidence 0.63 Published 2009 Journal Basic Res. Cardiol. Section Abstract Doc Link 19104749 Disease Relevance 0.06 Pain Relevance 1.23
However, this inhibitor neither modifies the morphine withdrawal induced Fos expression nor the increase of nonphosphorylated TH levels.
Phosphorylation (nonphosphorylated) of TH associated with withdrawal and morphine
10) Confidence 0.60 Published 2007 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 17216288 Disease Relevance 0.13 Pain Relevance 1.42
We also measured expression levels of TH and phosphorylated ERK(1/2) (pERK(1/2)), and found that both are up-regulated following morphine withdrawal.
Phosphorylation (phosphorylated) of TH associated with withdrawal and morphine
11) Confidence 0.58 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19545278 Disease Relevance 0.22 Pain Relevance 1.01
The present findings demonstrate that the enhancement of total TH expression and the increase of the phosphorylation state of TH during morphine withdrawal are dependent on PKA and ERK and suggest that these transduction pathways might contribute to the activation of the cardiac catecholaminergic neurons in response to morphine- withdrawal.
Phosphorylation (phosphorylation) of TH in neurons associated with withdrawal and morphine
12) Confidence 0.55 Published 2009 Journal Basic Res. Cardiol. Section Abstract Doc Link 19104749 Disease Relevance 0 Pain Relevance 0.97
ERK1/2 and tyrosine hydroxylase (TH) phosphorylation was determined by quantitative blot immunolabeling using phosphorylation state-specific antibodies.
Phosphorylation (phosphorylation) of tyrosine hydroxylase
13) Confidence 0.53 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19567779 Disease Relevance 0 Pain Relevance 1.33
The present findings demonstrate that the enhancement of ERK1/2 expression and the phosphorylation state of TH at Ser31 during morphine withdrawal are dependent on PKA and suggest cross-talk between PKA and ERK1/2 transduction pathway mediating morphine withdrawal-induced activation (phosphorylation) of TH.
Phosphorylation (phosphorylation) of TH associated with withdrawal and morphine
14) Confidence 0.53 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19567779 Disease Relevance 0 Pain Relevance 1.19
Naloxone-induced morphine withdrawal activates ERK1/2 and phosphorylates TH at Ser31 in the right and left ventricle, with an increase in the mean arterial blood pressure and heart rate.
Phosphorylation (phosphorylates) of TH in blood associated with narcan, withdrawal and morphine
15) Confidence 0.46 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19567779 Disease Relevance 0 Pain Relevance 1.33
The present findings demonstrate that the enhancement of ERK1/2 expression and the phosphorylation state of TH at Ser31 during morphine withdrawal are dependent on PKA and suggest cross-talk between PKA and ERK1/2 transduction pathway mediating morphine withdrawal-induced activation (phosphorylation) of TH.
Phosphorylation (phosphorylation) of TH associated with withdrawal and morphine
16) Confidence 0.46 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19567779 Disease Relevance 0 Pain Relevance 1.29
The ability of morphine withdrawal to activate ERK that phosphorylates TH at Ser31 was reduced by HA-1004.
Phosphorylation (phosphorylates) of TH associated with withdrawal and morphine
17) Confidence 0.46 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19567779 Disease Relevance 0 Pain Relevance 1.39
In the NAc, chronic, but not acute, morphine and cocaine treatments decreased the phosphorylation state of tyrosine hydroxylase, without a change in its total amount.
Phosphorylation (phosphorylation) of tyrosine hydroxylase in NAc associated with nucleus accumbens, cocaine and morphine
18) Confidence 0.34 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1675665 Disease Relevance 0 Pain Relevance 1.25
Pre-treatment with the MAPK specific inhibitor (U0126) or the adenylate cyclase inhibitor dideoxyadenosine (ddA) abolished the butyrate-induced: (i) accumulation of TH mRNA, (ii) the phosphorylation of ERK1/2 as well as (iii) CREB phosphorylation.
Phosphorylation (phosphorylation) of TH mRNA
19) Confidence 0.31 Published 2006 Journal Brain Res. Section Abstract Doc Link 16854387 Disease Relevance 0 Pain Relevance 0
We studied levels of tyrosine hydroxylase immunoreactivity and phosphorylation state in the ventral tegmental area (VTA) and nucleus accumbens (NAc) in an effort to understand better the mechanisms by which these brain reward regions are influenced by opiates and cocaine.
Phosphorylation (phosphorylation) of tyrosine hydroxylase in brain associated with nucleus accumbens, ventral tegmentum, opiate and cocaine
20) Confidence 0.26 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1675665 Disease Relevance 0 Pain Relevance 0.81

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox