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Context Info
Confidence 0.43
First Reported 1991
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.06
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) nucleus (Th)
response to stress (Th) cytoplasm (Th)
Anatomy Link Frequency
NAc 2
Th (Rattus norvegicus)
Pain Link Frequency Relevance Heat
noradrenaline 1 100.00 Very High Very High Very High
Morphine 18 99.90 Very High Very High Very High
cocaine 7 99.76 Very High Very High Very High
Nucleus accumbens 3 98.84 Very High Very High Very High
withdrawal 7 90.80 High High
Substantia nigra 1 90.48 High High
Ventral tegmentum 3 88.60 High High
opiate 1 87.64 High High
narcan 4 80.96 Quite High
addiction 2 72.64 Quite High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 1 59.88 Quite High
Drug Dependence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When HA-1004 (40 nmol/day), inhibitor of cyclic AMP dependent protein kinase (PKA) was infused, concomitantly with morphine, it diminished the increase in noradrenaline (NA) turnover, total TH expression (95.76 +/- 4.1 %, P < 0.01) and TH phosphorylation at Ser40 (85.5 +/- 11%, P < 0.01) in morphine-withdrawn rats.
Negative_regulation (diminished) of Phosphorylation (phosphorylation) of TH associated with noradrenaline and morphine
1) Confidence 0.43 Published 2009 Journal Basic Res. Cardiol. Section Abstract Doc Link 19104749 Disease Relevance 0.06 Pain Relevance 1.26
In the NAc, chronic, but not acute, morphine and cocaine treatments decreased the phosphorylation state of tyrosine hydroxylase, without a change in its total amount.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of tyrosine hydroxylase in NAc associated with nucleus accumbens, cocaine and morphine
2) Confidence 0.24 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1675665 Disease Relevance 0 Pain Relevance 1.25

General Comments

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