INT136455

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.15
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sp1) intracellular (Sp1) DNA binding (Sp1)
transcription factor binding (Sp1) cytoplasm (Sp1)
Sp1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 2 75.28 Quite High
Pancreatic Cancer 4 74.40 Quite High
Cancer 6 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Tolfenamic acid is a new antipancreatic cancer NSAID that activates degradation of transcription factors Sp1, Sp3, and Sp4; reduces VEGF expression; and decreases tumor growth and metastasis.


Positive_regulation (activates) of Protein_catabolism (degradation) of Sp1
1) Confidence 0.49 Published 2006 Journal J. Natl. Cancer Inst. Section Body Doc Link 16788159 Disease Relevance 0 Pain Relevance 0
RESULTS: Tolfenamic acid and structurally related biaryl derivatives induced degradation of Sp1, Sp3, and Sp4 in pancreatic cancer cells.
Positive_regulation (induced) of Protein_catabolism (degradation) of Sp1
2) Confidence 0.35 Published 2006 Journal J. Natl. Cancer Inst. Section Body Doc Link 16788159 Disease Relevance 0.15 Pain Relevance 0

General Comments

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