INT136458

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 11
Disease Relevance 1.53
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sp3) intracellular (Sp3) DNA binding (Sp3)
Anatomy Link Frequency
neuronal 1
Sp3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 117 99.80 Very High Very High Very High
mu opioid receptor 80 99.68 Very High Very High Very High
cINOD 2 99.02 Very High Very High Very High
Inflammatory response 27 34.72 Quite Low
Inflammation 36 11.12 Low Low
Pain 9 5.00 Very Low Very Low Very Low
IPN 9 5.00 Very Low Very Low Very Low
Morphine 3 5.00 Very Low Very Low Very Low
opioid receptor 3 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 14 100.00 Very High Very High Very High
Pancreatic Cancer 2 99.44 Very High Very High Very High
INFLAMMATION 64 98.74 Very High Very High Very High
Metastasis 1 98.32 Very High Very High Very High
Cancer 12 97.06 Very High Very High Very High
Obesity 18 90.80 High High
Disease 31 79.04 Quite High
Disorder Of Lipid Metabolism 18 77.08 Quite High
Atherosclerosis 99 76.36 Quite High
Cytomegalovirus Infection 18 18.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclooxygenase inhibitors decrease Sp1 expression in cancer cells, and therefore different structural classes of nonsteroidal anti-inflammatory drugs (NSAIDs) were screened for their ability to decrease levels of Sp1, Sp3, and Sp4 and to decrease pancreatic tumor growth and metastasis in an in vivo model.
Negative_regulation (decrease) of Sp3 associated with inflammation, cancer, pancreatic cancer, cinod and metastasis
1) Confidence 0.39 Published 2006 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 16788159 Disease Relevance 0.65 Pain Relevance 0.20
Evidence of the neuron-restrictive silencer factor (NRSF) interaction with Sp3 and its synergic repression to the mu opioid receptor (MOR) gene

Previously, we reported that the neuron-restrictive silencer element (NRSE) of mu opioid receptor (MOR) functions as a critical regulator to repress the MOR transcription in specific neuronal cells, depending on neuron-restriction silence factor (NRSF) expression levels [C.S.Kim, C.K.Hwang, H.S.Choi, K.Y.Song, P.Y.Law, L.N.Wei and H.H.Loh (2004) J.

Negative_regulation (repression) of Sp3 in neuronal associated with repression and mu opioid receptor
2) Confidence 0.36 Published 2006 Journal Nucleic Acids Research Section Title Doc Link PMC1702488 Disease Relevance 0.10 Pain Relevance 0.35
-mediated downregulation of murine growth hormone receptor expression has been shown to be due to inhibition of Sp1 and Sp3 binding [30].
Negative_regulation (inhibition) of Sp3
3) Confidence 0.28 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.06
Such a mechanism might therefore be common in transcriptional inhibition through Sp1/Sp3.
Negative_regulation (inhibition) of Sp1/Sp3
4) Confidence 0.28 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.07 Pain Relevance 0.03
-mediated decrease in Sp1/Sp3 binding was analysed by EMSA.
Negative_regulation (decrease) of Sp1/Sp3
5) Confidence 0.28 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.05
To determine whether the PI3K pathway was also involved in the cytokine-mediated reduction of Sp1/Sp3 binding to its recognition sequence in the LPL gene, the effect of pre-treatment of the cells with three different concentrations of the PI3K inhibitor LY294002 on the IFN-?
Negative_regulation (reduction) of Sp1/Sp3 associated with cytokine
6) Confidence 0.28 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.05
-mediated suppression of Sp1/Sp3 binding (Fig. 7C).
Negative_regulation (suppression) of Sp1/Sp3
7) Confidence 0.28 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.03
-mediated reduction of Sp1/Sp3 binding to the LPL gene.
Negative_regulation (reduction) of Sp1/Sp3
8) Confidence 0.28 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.04
-mediated reduction of Sp1/Sp3 binding to its recognition sequence in the LPL gene could be attenuated by incubation of the cells with 10 µM and 40 µM of the CK2 inhibitor apigenin [9,16–19].
Negative_regulation (reduction) of Sp1/Sp3
9) Confidence 0.28 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.05
In addition, as mTOR is also associated with translational regulation [24,27], it could potentially be involved in the reduction of Sp3 polypeptide levels observed when the cells are treated with IFN-?.
Negative_regulation (reduction) of Sp3
10) Confidence 0.28 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.31 Pain Relevance 0.04
-mediated reduction in Sp1/Sp3 binding.
Negative_regulation (reduction) of Sp1/Sp3
11) Confidence 0.28 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.40 Pain Relevance 0.05

General Comments

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