INT136459

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Context Info
Confidence 0.64
First Reported 2006
Last Reported 2006
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 11
Disease Relevance 1.97
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sp3) intracellular (Sp3) DNA binding (Sp3)
Anatomy Link Frequency
bladder 2
NS20Y 2
liver 1
HeLa 1
upper 1
Sp3 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 480 99.20 Very High Very High Very High
cINOD 8 98.84 Very High Very High Very High
Inflammation 84 54.96 Quite High
Inflammatory response 8 26.44 Quite Low
Morphine 18 5.00 Very Low Very Low Very Low
opioid receptor 18 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Analgesic 6 5.00 Very Low Very Low Very Low
Glutamate receptor 6 5.00 Very Low Very Low Very Low
interstitial cystitis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 29 100.00 Very High Very High Very High
Pancreatic Cancer 6 99.44 Very High Very High Very High
Overactive Bladder 122 99.16 Very High Very High Very High
INFLAMMATION 99 98.56 Very High Very High Very High
Metastasis 5 98.32 Very High Very High Very High
Repression 84 83.52 Quite High
Increased Venous Pressure Under Development 2 5.32 Low Low
Disease 32 5.00 Very Low Very Low Very Low
Targeted Disruption 16 5.00 Very Low Very Low Very Low
Bladder Cancer 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Within the Sp family transcription factors, Sp1 and Sp3 are ubiquitously expressed in mammalian cells.
Gene_expression (expressed) of Sp3
1) Confidence 0.64 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.13
In PC12 cells (NRSF negative but Sp3 positive), the NRSF-associated complex (the upper complex in lane 7) was not detected (data not shown).
Neg (negative) Gene_expression (negative) of Sp3 in upper
2) Confidence 0.56 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.03
ChIP and re-ChIP assay revealed that Sp3 and NRSF were presented together on 188 bp MOR DNA segment for synergic downregulation of MOR expression
Gene_expression (presented) of Sp3 associated with mu opioid receptor
3) Confidence 0.56 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.22
The identity of the transcriptional repressor that binds to the newly identified GC box was first hinted by co-immunoprecipitation of the Sp3 factor with NRSF in both HeLa and NS20Y nuclear extracts (Figure 4).
Gene_expression (immunoprecipitation) of Sp3 factor in NS20Y
4) Confidence 0.56 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.19
However, our current and previous data strongly suggest that the regulatory action of Sp3 factors is promoter- and cellular context dependent at least in the MOR gene expression because (i) only the full-length Sp3 can interact with NRSF in co-immunoprecipitation experiment whereas all three isoforms of Sp3 are expressed in NS20Y cells (Figure 4C), (ii) two short isoforms of Sp3 act as repressors by binding to the promoter element located at ?
Gene_expression (expressed) of Sp3 in NS20Y associated with mu opioid receptor
5) Confidence 0.50 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.15 Pain Relevance 0.20
BACKGROUND: Sp1, Sp3, and Sp4 are transcription factors that regulate cell proliferation and vascular endothelial growth factor (VEGF) expression and are overexpressed in many cancer cell lines.
Gene_expression (overexpressed) of Sp3 associated with cancer
6) Confidence 0.45 Published 2006 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 16788159 Disease Relevance 0.44 Pain Relevance 0.16
In the mouse model for pancreatic cancer, treatment with tolfenamic acid (50 mg/kg of body weight), compared with control treatment, statistically significantly decreased tumor growth and weight (P = .005), liver metastasis (P = .027), and levels of Sp3 and VEGF (P = .009) and Sp1 and Sp4 (P = .006) proteins in tumors.
Gene_expression (levels) of Sp3 in liver
7) Confidence 0.40 Published 2006 Journal J. Natl. Cancer Inst. Section Body Doc Link 16788159 Disease Relevance 0.11 Pain Relevance 0
Cyclooxygenase inhibitors decrease Sp1 expression in cancer cells, and therefore different structural classes of nonsteroidal anti-inflammatory drugs (NSAIDs) were screened for their ability to decrease levels of Sp1, Sp3, and Sp4 and to decrease pancreatic tumor growth and metastasis in an in vivo model.
Gene_expression (levels) of Sp3 associated with inflammation, cancer, pancreatic cancer, cinod and metastasis
8) Confidence 0.40 Published 2006 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 16788159 Disease Relevance 0.65 Pain Relevance 0.20
The regulatory network for the control bladder mucosa (MC) was obtained in comparison to detrusor control and contained the following over-represented TREs: GA-binding protein (GABP), YY1 (yin yang 1), SF-1 (steroidogenic factor-1), EF2, CRE-BP1, and Sp-3 (trans-acting transcription factor 3).
Gene_expression (represented) of Sp-3 in bladder associated with overactive bladder
9) Confidence 0.36 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.31 Pain Relevance 0.08
The regulatory network for the control bladder mucosa (MC) was obtained in comparison to detrusor control and contained the following over-represented TREs: GA-binding protein (GABP), YY1 (yin yang 1), SF-1 (steroidogenic factor-1), EF2, CRE-BP1, and Sp-3 (trans-acting transcription factor 3).
Gene_expression (represented) of trans-acting transcription factor 3 in bladder associated with overactive bladder
10) Confidence 0.31 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.31 Pain Relevance 0.08
The identity of the transcriptional repressor that binds to the newly identified GC box was first hinted by co-immunoprecipitation of the Sp3 factor with NRSF in both HeLa and NS20Y nuclear extracts (Figure 4).
Gene_expression (immunoprecipitation) of Sp3 factor in HeLa
11) Confidence 0.19 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.19

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