INT136460

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.30
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.99
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sp1) intracellular (Sp1) DNA binding (Sp1)
transcription factor binding (Sp1) cytoplasm (Sp1)
Sp1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 2 98.84 Very High Very High Very High
cytokine 26 80.60 Quite High
Inflammatory response 6 34.08 Quite Low
Inflammation 8 5.00 Very Low Very Low Very Low
IPN 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 2 99.24 Very High Very High Very High
INFLAMMATION 15 98.56 Very High Very High Very High
Metastasis 1 98.12 Very High Very High Very High
Cancer 5 96.88 Very High Very High Very High
Obesity 4 91.76 High High
Disease 6 65.00 Quite High
Disorder Of Lipid Metabolism 4 63.04 Quite High
Atherosclerosis 22 62.32 Quite High
Cytomegalovirus Infection 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclooxygenase inhibitors decrease Sp1 expression in cancer cells, and therefore different structural classes of nonsteroidal anti-inflammatory drugs (NSAIDs) were screened for their ability to decrease levels of Sp1, Sp3, and Sp4 and to decrease pancreatic tumor growth and metastasis in an in vivo model.
Negative_regulation (levels) of Sp1 associated with inflammation, cancer, pancreatic cancer, cinod and metastasis
1) Confidence 0.30 Published 2006 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 16788159 Disease Relevance 0.65 Pain Relevance 0.20
The precise mechanisms underlying such regulation remain to be determined but could include direct phosphorylation-mediated reduction of Sp1 binding.
Negative_regulation (reduction) of Sp1
2) Confidence 0.23 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.34 Pain Relevance 0.04
-mediated downregulation of murine growth hormone receptor expression has been shown to be due to inhibition of Sp1 and Sp3 binding [30].
Negative_regulation (inhibition) of Sp1
3) Confidence 0.23 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.06

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox