INT136462

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.65
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ptgs1, Sp1) nucleus (Ptgs1, Sp1) nuclear envelope (Ptgs1)
Golgi apparatus (Ptgs1) endoplasmic reticulum (Ptgs1) intracellular (Sp1)
Ptgs1 (Mus musculus)
Sp1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 2 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 3 100.00 Very High Very High Very High
INFLAMMATION 1 97.20 Very High Very High Very High
Pancreatic Cancer 2 92.56 High High
Metastasis 1 91.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclooxygenase inhibitors decrease Sp1 expression in cancer cells, and therefore different structural classes of nonsteroidal anti-inflammatory drugs (NSAIDs) were screened for their ability to decrease levels of Sp1, Sp3, and Sp4 and to decrease pancreatic tumor growth and metastasis in an in vivo model.
Negative_regulation (inhibitors) of Cyclooxygenase Negative_regulation (decrease) of Gene_expression (expression) of Sp1 associated with inflammation, cancer, pancreatic cancer, cinod and metastasis
1) Confidence 0.01 Published 2006 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 16788159 Disease Relevance 0.65 Pain Relevance 0.19

General Comments

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