INT136465

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 7.05
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hif1a) signal transduction (Hif1a) nucleolus (Hif1a)
nucleus (Hif1a) protein binding transcription factor activity (Hif1a) DNA binding (Hif1a)
Anatomy Link Frequency
brain 1
Hif1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 1 98.16 Very High Very High Very High
Neurotransmitter 6 91.20 High High
Calcium channel 7 87.32 High High
adenocard 12 85.92 High High
potassium channel 15 84.80 Quite High
ischemia 15 75.68 Quite High
cINOD 1 74.08 Quite High
Glutamate receptor 16 70.96 Quite High
nMDA receptor 36 50.00 Quite Low
isoflurane 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 17 100.00 Very High Very High Very High
Hypoxia 764 99.84 Very High Very High Very High
INFLAMMATION 2 98.16 Very High Very High Very High
Stress 22 96.96 Very High Very High Very High
Injury 6 95.92 Very High Very High Very High
Shock 1 86.48 High High
Cv Unclassified Under Development 8 75.68 Quite High
Ulcers 1 75.08 Quite High
Adhesions 4 58.00 Quite High
Retina Disease 8 57.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, NO could also be an important modulator regulating the HIF-1?
Regulation (regulating) of HIF-1
1) Confidence 0.39 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.76 Pain Relevance 0.08
In this context, it has been reported that DMOG alone had minor effect on HIF-1?
Regulation (effect) of HIF-1
2) Confidence 0.39 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.33 Pain Relevance 0
Even for those that are under the control of HIF-1, upregulation may require additional factors as well [65].
Regulation (control) of HIF-1
3) Confidence 0.19 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 1.04 Pain Relevance 0.06
This may not be an exhaustive list of the HIF-1 regulated genes, but only a few of the genes that were altered in our study are on that list.
Regulation (regulated) of HIF-1
4) Confidence 0.19 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.98 Pain Relevance 0.04
Thus, as in other tissues, it is likely that control of HIF-1?
Spec (likely) Regulation (control) of HIF-1
5) Confidence 0.19 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.84 Pain Relevance 0
Similarly, Bernaudin et al. [43] found increased expression of 18 genes in the neonatal rat brain following hypoxia (8% O2 for 3 h) including several known hypoxia inducible genes such as MAP kinase phosphatase-1 (MKP-1), several HIF-1 target genes including VEGF and GLUT-1, genes implicated in apoptosis, signal transduction molecules, and transcription factors.
Regulation (target) of HIF-1 in brain associated with hypoxia and apoptosis
6) Confidence 0.19 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.97 Pain Relevance 0.22
In addition, it has been reported that NO can modulate the level of HIF-1?
Regulation (modulate) of HIF-1
7) Confidence 0.17 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.77 Pain Relevance 0.09
HIF-1- and apoptosis-related genes were modulated by hypoxia.
Regulation (modulated) of HIF-1 associated with hypoxia and apoptosis
8) Confidence 0.11 Published 2006 Journal Digestion Section Abstract Doc Link 16788290 Disease Relevance 1.37 Pain Relevance 0.12

General Comments

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