INT136467

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.57
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Areg) nucleus (Areg) intracellular (Areg)
cytoplasm (Areg)
Areg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cannabinoid 18 96.28 Very High Very High Very High
Inflammation 2 95.40 Very High Very High Very High
cINOD 1 66.12 Quite High
Endocannabinoid 8 65.68 Quite High
Pain 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 1 100.00 Very High Very High Very High
Glioma 1 99.58 Very High Very High Very High
Hypoxia 8 99.16 Very High Very High Very High
Apoptosis 5 98.00 Very High Very High Very High
Injury 2 96.24 Very High Very High Very High
Stress 2 95.76 Very High Very High Very High
INFLAMMATION 3 95.40 Very High Very High Very High
Cancer 42 83.20 Quite High
Frailty 23 80.92 Quite High
Colon Cancer 2 80.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In rat C6 glioma cells, the level of expression of the EGFR ligand amphiregulin is a factor determining the degree of resistance of the cells to the deleterious effects of cannabinoids [28].
Gene_expression (expression) of amphiregulin associated with cannabinoid and glioma
1) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009725 Disease Relevance 0.88 Pain Relevance 0.14
In particular, the expression of heat shock protein-70, amphiregulin and cyclooxygenase-2 were upregulated during reoxygenation following hypoxia, suggesting that these upregulations may play an important role in maintaining cell survival and supporting cell function.
Gene_expression (expression) of amphiregulin associated with hypoxia and shock
2) Confidence 0.41 Published 2006 Journal Digestion Section Abstract Doc Link 16788290 Disease Relevance 1.41 Pain Relevance 0.11
Estrogens are known to stimulate expression of other members of this family, such as amphiregulin [30].
Gene_expression (expression) of amphiregulin
3) Confidence 0.09 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2453134 Disease Relevance 0.28 Pain Relevance 0

General Comments

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