INT136488

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 3.53
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (LMNA) nuclear envelope (LMNA) structural molecule activity (LMNA)
nucleus (LMNA) cytoplasm (LMNA)
Anatomy Link Frequency
neuronal 1
LMNA (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 1 85.68 High High
Inflammation 3 85.04 High High
Neurotransmitter 6 55.92 Quite High
imagery 16 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
backache 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 43 99.66 Very High Very High Very High
Metabolic Syndrome 2 99.48 Very High Very High Very High
Coronary Heart Disease 3 99.04 Very High Very High Very High
Sprains And Strains 166 98.92 Very High Very High Very High
Apoptosis 7 98.72 Very High Very High Very High
Increased Venous Pressure Under Development 9 97.76 Very High Very High Very High
Hutchinson-gilford Progeria Syndrome 7 94.24 High High
Aging 12 92.12 High High
Metastasis 1 91.60 High High
Cancer 1 87.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Granzyme B, caspase 3, lamin A/C, caspase 10 and caspase 4 were all up regulated.
Regulation (regulated) of lamin A/C
1) Confidence 0.60 Published 2007 Journal Virol J Section Body Doc Link PMC2042503 Disease Relevance 0.61 Pain Relevance 0.08
Changes in MUC1 staining were observed in PanIN-3 and IDC, and E-cadherin staining was seen in neoplastic tissues.
Regulation (Changes) of IDC
2) Confidence 0.44 Published 2006 Journal Rinsho Byori Section Abstract Doc Link 16789413 Disease Relevance 0.48 Pain Relevance 0.09
In the case of the pattern plaids, however, this attenuation was less pronounced for the LFP power and LFP–LFP coherence.
Regulation (pronounced) of LFP
3) Confidence 0.44 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2882822 Disease Relevance 0 Pain Relevance 0
In the case of the pattern plaids, however, this attenuation was less pronounced for the LFP power and LFP–LFP coherence.
Regulation (pronounced) of LFP
4) Confidence 0.44 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2882822 Disease Relevance 0 Pain Relevance 0
In the case of the pattern plaids, however, this attenuation was less pronounced for the LFP power and LFP–LFP coherence.
Regulation (pronounced) of LFP
5) Confidence 0.38 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2882822 Disease Relevance 0 Pain Relevance 0
Given the extreme forms of vascular disease seen in these two laminopathies, and the strong association of the metabolic syndrome with CAD we explored the role of LMNA variation in premature coronary disease.
Regulation (role) of LMNA associated with coronary artery disease, metabolic syndrome, coronary heart disease and increased venous pressure under development
6) Confidence 0.37 Published 2005 Journal BMC Med Genet Section Body Doc Link PMC1289285 Disease Relevance 2.03 Pain Relevance 0
In contrast to LFP amplitude, which showed significant laminar differences in the gamma-range only, LFP coherence of almost all frequencies segregated significantly between laminar compartments.


Regulation (segregated) of LFP
7) Confidence 0.33 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2928665 Disease Relevance 0 Pain Relevance 0
in affected FPLD3 subjects.
Regulation (affected) of FPLD3
8) Confidence 0.26 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1368963 Disease Relevance 0.16 Pain Relevance 0
Previous work has reported a phase difference between LFP and cell spiking of around –?
Regulation (reported) of LFP
9) Confidence 0.21 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2228402 Disease Relevance 0 Pain Relevance 0
The effect on LFP frequency ranges in these strains therefore appears to be robust, whereas, in D0067 (like dunce), the effect is weak.


Regulation (effect) of LFP associated with sprains and strains
10) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694981 Disease Relevance 0.10 Pain Relevance 0
Thus, modulating LFP activity by silencing distinct neuronal circuits should narrow the sources of neuronal synchronization resulting in the 20–30 Hz response to novelty.
Regulation (modulating) of LFP in neuronal
11) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694981 Disease Relevance 0 Pain Relevance 0.03
Indeed, LFP responsiveness to novelty in A0023 was also defective, most resembling D0067 by the absence of a strong frequency component in the LFP response (Figure 3D).
Regulation (responsiveness) of LFP
12) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694981 Disease Relevance 0 Pain Relevance 0
To confirm the LFP frequency effects found in D0264, D0067, and D0177, we repeated the novelty experiments with 50 or 25 s of training.
Regulation (effects) of LFP
13) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694981 Disease Relevance 0.07 Pain Relevance 0
LFP responsiveness to novelty was investigated by presenting distinct objects together following a training period during which flies were exposed to identical objects (Figure 3C).
Spec (investigated) Regulation (responsiveness) of LFP
14) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694981 Disease Relevance 0 Pain Relevance 0

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