INT136496

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2008
Negated 1
Speculated 2
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 3.72
Pain Relevance 6.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Accn3) cytoplasm (Accn3)
Anatomy Link Frequency
DRG 3
neurons 2
hair cells 1
Accn3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal nerve ligature 44 100.00 Very High Very High Very High
ASIC 27 100.00 Very High Very High Very High
dorsal root ganglion 24 99.64 Very High Very High Very High
induced neuropathy 4 99.24 Very High Very High Very High
qutenza 17 97.32 Very High Very High Very High
Pain 18 96.88 Very High Very High Very High
withdrawal 4 93.44 High High
nociceptor 20 88.52 High High
c fibre 4 88.04 High High
trigeminal ganglion 24 83.60 Quite High
Disease Link Frequency Relevance Heat
Nociception 29 100.00 Very High Very High Very High
Ganglion Cysts 63 99.60 Very High Very High Very High
Neuropathic Pain 4 99.24 Very High Very High Very High
Pain 14 96.88 Very High Very High Very High
Frailty 1 83.56 Quite High
Cough 5 78.16 Quite High
INFLAMMATION 7 64.12 Quite High
Hyperalgesia 6 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also examined immunoreactivity for acid-sensing ion channel 3 (ASIC3) in the dorsal root ganglion (DRG) of rats with L5 SNL.
Spec (examined) Regulation (immunoreactivity) of ASIC3 in DRG associated with ganglion cysts, dorsal root ganglion and spinal nerve ligature
1) Confidence 0.45 Published 2008 Journal Brain Res. Section Abstract Doc Link 18534561 Disease Relevance 0.68 Pain Relevance 1.18
Effects of selective spinal nerve ligation on acetic acid-induced nociceptive responses and ASIC3 immunoreactivity in the rat dorsal root ganglion.
Regulation (Effects) of ASIC3 in dorsal root ganglion associated with ganglion cysts, nociception, dorsal root ganglion and spinal nerve ligature
2) Confidence 0.45 Published 2008 Journal Brain Res. Section Title Doc Link 18534561 Disease Relevance 0.83 Pain Relevance 1.35
We also examined immunoreactivity for acid-sensing ion channel 3 (ASIC3) in the dorsal root ganglion (DRG) of rats with L5 SNL.
Spec (examined) Regulation (immunoreactivity) of acid-sensing ion channel 3 in DRG associated with ganglion cysts, dorsal root ganglion and spinal nerve ligature
3) Confidence 0.45 Published 2008 Journal Brain Res. Section Abstract Doc Link 18534561 Disease Relevance 0.68 Pain Relevance 1.18
In the ipsilateral L5 DRG, the proportion of ASIC3-ir neurons was not significantly affected by treatment.
Neg (not) Regulation (affected) of ASIC3 in neurons associated with dorsal root ganglion
4) Confidence 0.27 Published 2008 Journal Brain Res. Section Abstract Doc Link 18534561 Disease Relevance 0.79 Pain Relevance 1.43
Colocalization of ASIC3- and TRPV1-immunoreactivities was observed in roughly 10% of retrogradely labelled DRG neurons, both among pleural and pulmonary afferents.
Regulation (immunoreactivities) of ASIC3 in neurons
5) Confidence 0.23 Published 2006 Journal Respir Res Section Body Doc Link PMC1524950 Disease Relevance 0.36 Pain Relevance 0.46
No acid-pH-sensitive currents or ASIC immunoreactivity was found in hair cells.
Regulation (immunoreactivity) of ASIC in hair cells associated with asic
6) Confidence 0.22 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16790596 Disease Relevance 0.18 Pain Relevance 0.24
ASIC3 channels are highly sensitive to changes in extracellular pH and lactate and if activated by a substantial change in pH they desensitize significantly more rapidly than other ASIC channels [5,18,19].
Regulation (sensitive) of ASIC3 associated with asic
7) Confidence 0.15 Published 2005 Journal Mol Pain Section Body Doc Link PMC1283980 Disease Relevance 0.20 Pain Relevance 0.68

General Comments

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