INT13650

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Context Info
Confidence 0.50
First Reported 1989
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.69
Pain Relevance 4.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a)
signal transducer activity (Adra2a)
Anatomy Link Frequency
cerebral cortex 4
spinal cord 4
spinal 2
brainstem 1
hippocampus 1
Adra2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 11 100.00 Very High Very High Very High
depression 10 100.00 Very High Very High Very High
medulla 6 100.00 Very High Very High Very High
Clonidine 19 99.90 Very High Very High Very High
Hippocampus 9 99.84 Very High Very High Very High
Morphine 8 99.82 Very High Very High Very High
antagonist 8 99.44 Very High Very High Very High
Desipramine 7 99.32 Very High Very High Very High
Spinal cord 8 97.64 Very High Very High Very High
cerebral cortex 4 95.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 10 100.00 Very High Very High Very High
Opiate Addiction 2 81.44 Quite High
Drug Dependence 1 79.00 Quite High
Hypotension 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously, we have shown that dexmedetomidine and clonidine act upon spinal alpha 2 adrenoceptor, which appeared distinguishable from that acted upon by ST-91.
Positive_regulation (upon) of Gene_expression (distinguishable) of alpha 2 adrenoceptor in spinal associated with clonidine
1) Confidence 0.50 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8093729 Disease Relevance 0 Pain Relevance 0.61
It is suggested that DMI-facilitated FRA can be used as a test for alpha-2 adrenoceptor agonists which may act at presynaptic alpha-2 adrenoceptors in the spinal cord.
Positive_regulation (test) of Gene_expression (agonists) of alpha-2 adrenoceptor in spinal cord associated with desipramine, agonist and spinal cord
2) Confidence 0.48 Published 1991 Journal J. Neural Transm. Gen. Sect. Section Abstract Doc Link 1675858 Disease Relevance 0 Pain Relevance 0.82
Prazosin, an antagonist for alpha-1 adrenoceptors, enforced the alpha-2 adrenoceptor agonist-induced depression in both species. 6-Hydroxydopamine treatment, which reduced the norepinephrine concentrations in the rat cerebral cortex by 76%, increased the duration of the loss of righting reflex induced by xylazine indicating that central postsynaptic alpha-2 adrenoceptors might also be involved in this behavioral alteration.
Positive_regulation (enforced) of Gene_expression (depression) of alpha-2 adrenoceptor in cerebral cortex associated with depression, antagonist, agonist and cerebral cortex
3) Confidence 0.45 Published 1989 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2572006 Disease Relevance 0.26 Pain Relevance 0.72
Prazosin, an antagonist for alpha-1 adrenoceptors, enforced the alpha-2 adrenoceptor agonist-induced depression in both species. 6-Hydroxydopamine treatment, which reduced the norepinephrine concentrations in the rat cerebral cortex by 76%, increased the duration of the loss of righting reflex induced by xylazine indicating that central postsynaptic alpha-2 adrenoceptors might also be involved in this behavioral alteration.
Positive_regulation (agonist-induced) of Gene_expression (depression) of alpha-2 adrenoceptor in cerebral cortex associated with depression, antagonist, agonist and cerebral cortex
4) Confidence 0.45 Published 1989 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2572006 Disease Relevance 0.26 Pain Relevance 0.72
These data indicate that (1) inhibition of KCl-induced norepinephrine release by mivazerol is mediated by its action on alpha2-adrenergic receptors; (2) at concentrations selective for alpha2-adrenergic receptors, only mivazerol was effective in blocking the KCl-induced glutamate release in hippocampal tissue; and (3) at the same concentrations, both mivazerol and clonidine were unable to inhibit glutamate release in the spinal cord.
Positive_regulation (mediated) of Gene_expression (action) of alpha2-adrenergic in spinal cord associated with glutamate, spinal cord and clonidine
5) Confidence 0.32 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8764590 Disease Relevance 0 Pain Relevance 1.12
Yohimbine prevents morphine-induced changes of glial fibrillary acidic protein in brainstem and alpha2-adrenoceptor gene expression in hippocampus.
Positive_regulation (changes) of in brainstem Gene_expression (expression) of alpha2-adrenoceptor in hippocampus associated with medulla, hippocampus and morphine
6) Confidence 0.07 Published 2007 Journal Neurosci. Lett. Section Title Doc Link 17123717 Disease Relevance 0.16 Pain Relevance 0.94

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