INT136514

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.12
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.80
Pain Relevance 3.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grm1, Grm5) signal transducer activity (Grm1, Grm5) nucleus (Grm1)
cytoplasm (Grm5)
Anatomy Link Frequency
neuropil 1
Grm1 (Rattus norvegicus)
Grm5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 37 100.00 Very High Very High Very High
IPN 3 100.00 Very High Very High Very High
Morphine 9 98.96 Very High Very High Very High
tolerance 9 97.84 Very High Very High Very High
Analgesic 9 96.80 Very High Very High Very High
Pain 20 96.12 Very High Very High Very High
Dorsal horn 5 94.72 High High
Spinal cord 9 94.24 High High
Inflammation 6 93.08 High High
nMDA receptor 7 81.08 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Pain 3 100.00 Very High Very High Very High
Injury 3 97.44 Very High Very High Very High
Pain 20 96.12 Very High Very High Very High
INFLAMMATION 6 93.08 High High
Ganglion Cysts 2 47.60 Quite Low
Depression 2 45.72 Quite Low
Nociception 7 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 2 5.00 Very Low Very Low Very Low
Ketoacidosis 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compelling anatomical and electrophysiological studies have indicated the presence of mGluR1 and mGluR5 in the neuropil of all the trigeminal nuclei [15].
mGluR1 Binding (presence) of mGluR5 in neuropil
1) Confidence 0.12 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0 Pain Relevance 0.32
The aims of the present study were to assess: (i) the role of mGlu1 and mGlu5 receptors in inflammatory pain using selective antagonist EMQMCM, 1.25-5 mg/kg, as the mGlu1 receptor antagonist, and MPEP or MTEP, 2.5-10 mg/kg, as mGlu5 receptor antagonist; (ii) the possible interaction between mGlu1 and mGlu5 receptor antagonists and morphine; and (iii) whether tolerance develops to the analgesic effects of these antagonists after prolonged treatment.
mGlu1 Binding (interaction) of mGlu5 associated with analgesic, antagonist, ipn, tolerance and morphine
2) Confidence 0.07 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16793067 Disease Relevance 0.61 Pain Relevance 1.20
The aims of the present study were to assess: (i) the role of mGlu1 and mGlu5 receptors in inflammatory pain using selective antagonist EMQMCM, 1.25-5 mg/kg, as the mGlu1 receptor antagonist, and MPEP or MTEP, 2.5-10 mg/kg, as mGlu5 receptor antagonist; (ii) the possible interaction between mGlu1 and mGlu5 receptor antagonists and morphine; and (iii) whether tolerance develops to the analgesic effects of these antagonists after prolonged treatment.
mGlu1 Binding (interaction) of mGlu5 associated with analgesic, antagonist, ipn, tolerance and morphine
3) Confidence 0.07 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16793067 Disease Relevance 0.61 Pain Relevance 1.20
The aims of the present study were to assess: (i) the role of mGlu1 and mGlu5 receptors in inflammatory pain using selective antagonist EMQMCM, 1.25-5 mg/kg, as the mGlu1 receptor antagonist, and MPEP or MTEP, 2.5-10 mg/kg, as mGlu5 receptor antagonist; (ii) the possible interaction between mGlu1 and mGlu5 receptor antagonists and morphine; and (iii) whether tolerance develops to the analgesic effects of these antagonists after prolonged treatment.
mGlu1 Binding (interaction) of mGlu5 associated with analgesic, antagonist, ipn, tolerance and morphine
4) Confidence 0.07 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16793067 Disease Relevance 0.58 Pain Relevance 1.18

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox