INT136518

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Context Info
Confidence 0.29
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.31
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6ST) extracellular region (IL6ST) plasma membrane (IL6ST)
Anatomy Link Frequency
platelet 1
IL6ST (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 97.52 Very High Very High Very High
chemokine 2 91.72 High High
Inflammation 28 90.84 High High
alcohol 1 88.76 High High
lidocaine 1 83.64 Quite High
agonist 2 50.00 Quite Low
Arthritis 1 27.28 Quite Low
rheumatoid arthritis 3 10.32 Low Low
cINOD 5 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 32 90.84 High High
Dislocations 1 83.92 Quite High
Cancer 3 75.20 Quite High
Reprotox - General 1 1 61.20 Quite High
Arthritis 2 27.28 Quite Low
Disease 2 16.00 Low Low
Rheumatoid Arthritis 3 10.32 Low Low
Cytomegalovirus Infection 7 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low
Bacterial Respiratory Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among genes related to immunity, we detected a significant down-regulation in IFNGR1 (interferon gamma receptor), IL6ST (interleukin 6 signal transducer) and several suppressors of cytokine signalling molecules (SOCS2, SOCS4, SOCS5 and SOCS6).
Regulation (regulation) of IL6ST associated with cytokine
1) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.23 Pain Relevance 0.23
We suggest that EDTA induces alterations in membrane glycoprotein structure and affect MLF by altering lipid-protein interactions, and thus triggers signal transduction in the course of platelet activation.
Regulation (alterations) of membrane glycoprotein in platelet
2) Confidence 0.05 Published 1998 Journal Platelets Section Abstract Doc Link 16793756 Disease Relevance 0.08 Pain Relevance 0.13

General Comments

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