INT136522

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.53
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Prokr1) plasma membrane (Prokr1) signal transducer activity (Prokr1)
Anatomy Link Frequency
B lymphocytes 2
capsule 1
leukocyte 1
neurons 1
Prokr1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 1 99.96 Very High Very High Very High
dorsal root ganglion 29 98.92 Very High Very High Very High
qutenza 36 98.64 Very High Very High Very High
Cannabinoid 1 98.52 Very High Very High Very High
nociceptor 4 97.48 Very High Very High Very High
cytokine 137 97.04 Very High Very High Very High
Inflammatory response 23 95.92 Very High Very High Very High
chemokine 7 91.24 High High
agonist 23 88.64 High High
Peripheral nervous system 1 87.24 High High
Disease Link Frequency Relevance Heat
Cryptococcus Infection 1 99.16 Very High Very High Very High
Ganglion Cysts 29 98.92 Very High Very High Very High
Nociception 34 98.84 Very High Very High Very High
INFLAMMATION 105 95.52 Very High Very High Very High
Infection 14 91.20 High High
Injury 7 90.80 High High
Hyperalgesia 12 87.12 High High
Colitis 5 86.20 High High
Mycobacterial Infection 6 84.00 Quite High
Pain 16 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When compared with wild-type littermates, mice lacking the pkr1 gene showed impaired responsiveness to noxious heat, mechanical stimuli, capsaicin, and protons.
Negative_regulation (lacking) of pkr1 gene associated with qutenza
1) Confidence 0.58 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16793879 Disease Relevance 0.89 Pain Relevance 1.02
Our expression results also reveal that PKR1 is the dominant receptor expressed in primary nociceptive DRG neurons, consistent with the genetic study that mice lacking the PKR1 gene showed impaired response to capsaicin [13].
Negative_regulation (lacking) of PKR1 in neurons associated with nociception, dorsal root ganglion and qutenza
2) Confidence 0.38 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 1.22 Pain Relevance 0.84
In BMM, Prokr1 was transiently induced by LPS (37-fold at 6 h) but repressed in TEPM (20-fold at 7 h).
Negative_regulation (repressed) of Prokr1
3) Confidence 0.37 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.44 Pain Relevance 0.07
The effects of LPS could even be opposing in these two cell populations; Prokr1 was induced 37-fold by LPS in BMM (6 h), but repressed 20-fold in TEPM (7 h) (Figure 3c).
Negative_regulation (repressed) of Prokr1
4) Confidence 0.37 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.11 Pain Relevance 0.03
In these cells we observed a predominance of PROKR 1 transcript in comparison to PROKR 2.
Negative_regulation (predominance) of PROKR
5) Confidence 0.26 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0 Pain Relevance 0.04
Both PROKR 1 and 2 are more highly expressed in CD11b+ cells than in T and B lymphocytes; moreover in this cell type a predominance of PROKR 1 transcripts over PROKR 2 is found.
Negative_regulation (predominance) of PROKR in B lymphocytes
6) Confidence 0.26 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.06 Pain Relevance 0.05
Lower and similar expression of both receptors was found in CD3+ and in CD19+ cells, with a slight predominance of PROKR 2 in B lymphocytes.


Negative_regulation (predominance) of PROKR in B lymphocytes
7) Confidence 0.22 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0 Pain Relevance 0.07
Hypervirulence has been also observed in other fungal species such as Cryptococcus neoformans where perturbation in cAMP signalling by inactivation of PKR1 (encoding the PKA regulatory subunit) resulted in capsule overproduction [40].
Negative_regulation (inactivation) of PKR1 in capsule associated with cryptococcus infection
8) Confidence 0.16 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2607542 Disease Relevance 0.32 Pain Relevance 0
Significant increases in neuronal receptors, such as transient receptor potential A1 (TRPA1), cannabinoid type 1 receptor, neurokinin 1 receptor (NK1R) and delta-opioid receptor; prokineticin-1 receptor; and soluble mediators, such as prodynorphin, proenkephalin1, NK1, prokineticin-1 and secretory leukocyte protease inhibitor, occurred.
Negative_regulation (inhibitor) of prokineticin-1 receptor in leukocyte associated with cannabinoid and opioid receptor
9) Confidence 0.16 Published 2007 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 17509021 Disease Relevance 0.49 Pain Relevance 0.59

General Comments

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