INT136525

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 2.90
Pain Relevance 3.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Prokr1, Trpv1) cytosol (Trpv1) transport (Trpv1)
signal transduction (Prokr1) transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
nociceptor 2
Prokr1 (Mus musculus)
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 15 100.00 Very High Very High Very High
IPN 6 100.00 Very High Very High Very High
Pain 15 99.84 Very High Very High Very High
nociceptor 9 99.84 Very High Very High Very High
Neuropeptide 3 97.80 Very High Very High Very High
agonist 6 93.44 High High
dorsal root ganglion 9 91.68 High High
Peripheral nervous system 3 87.88 High High
Inflammation 6 85.48 High High
Thermal hyperalgesia 3 81.40 Quite High
Disease Link Frequency Relevance Heat
Nociception 9 100.00 Very High Very High Very High
Inflammatory Pain 6 100.00 Very High Very High Very High
Pain 6 99.84 Very High Very High Very High
Ganglion Cysts 9 91.68 High High
INFLAMMATION 6 85.48 High High
Hyperalgesia 9 81.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings indicate a modulatory role of PKR1 in acute nociception and inflammatory pain and disclose a pharmacological interaction between PKR1 and TRPV1 in nociceptor activation and sensitization.
PKR1 Binding (interaction) of TRPV1 in nociceptor associated with nociception, nociceptor and ipn
1) Confidence 0.39 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16793879 Disease Relevance 1.05 Pain Relevance 1.15
These findings indicate a modulatory role of PKR1 in acute nociception and inflammatory pain and disclose a pharmacological interaction between PKR1 and TRPV1 in nociceptor activation and sensitization.
PKR1 Binding (interaction) of TRPV1 in nociceptor associated with nociception, nociceptor and ipn
2) Confidence 0.37 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16793879 Disease Relevance 1.02 Pain Relevance 1.12
Impaired nociception and inflammatory pain sensation in mice lacking the prokineticin receptor PKR1: focus on interaction between PKR1 and the capsaicin receptor TRPV1 in pain behavior.
PKR1 Binding (interaction) of TRPV1 associated with nociception, pain, qutenza and ipn
3) Confidence 0.37 Published 2006 Journal J. Neurosci. Section Title Doc Link 16793879 Disease Relevance 0.83 Pain Relevance 1.49

General Comments

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