INT136540

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Context Info
Confidence 0.27
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 0.81
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (CYP2C9, Ugt1a6a) small molecule metabolic process (CYP2C9) oxidoreductase activity (CYP2C9)
transferase activity, transferring glycosyl groups (Ugt1a6a) enzyme binding (Ugt1a6a) protein complex (Ugt1a6a)
CYP2C9 (Homo sapiens)
Ugt1a6a (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 8 100.00 Very High Very High Very High
aspirin 4 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 100.00 Very High Very High Very High
Colon Cancer 4 99.12 Very High Very High Very High
Adenoma 2 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, interactions between UGT1A6 variants or variants of another enzyme that metabolizes nonsteroidal anti-inflammatory drugs (NSAIDs), cytochrome P4502C9 (CYP2C9), and NSAIDs in the prevention of colorectal cancer have not been studied extensively.
cytochrome P4502C9 Binding (interactions) of UGT1A6 associated with inflammation, colon cancer and cinod
1) Confidence 0.27 Published 2006 Journal Clin. Gastroenterol. Hepatol. Section Abstract Doc Link 16797247 Disease Relevance 0.45 Pain Relevance 0.42
Interactions between CYP2C9 and UGT1A6 polymorphisms and nonsteroidal anti-inflammatory drugs in colorectal cancer prevention.
CYP2C9 Binding (Interactions) of UGT1A6 associated with aspirin, inflammation, colon cancer and cinod
2) Confidence 0.27 Published 2006 Journal Clin. Gastroenterol. Hepatol. Section Title Doc Link 16797247 Disease Relevance 0.37 Pain Relevance 0.44

General Comments

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