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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.37
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (FOXI2) transcription factor binding (FOXI2)
Anatomy Link Frequency
brain 1
FOXI2 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 5 100.00 Very High Very High Very High
mu opioid receptor 1 94.24 High High
agonist 1 68.80 Quite High
Analgesic 1 52.16 Quite High
Central nervous system 1 30.24 Quite Low
narcan 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

5 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas the BU224 hybrid molecules bound to the mu-opioid receptor and the I2-IBS in the micromolar to low micromolar range, the alkaneguanidine series exhibited remarkable affinities in the nanomolar range for both receptors. [35S]GTPgammaS functional assays were performed on human postmortem brain membranes with selected ligands from each series (4f and 8g) showing the highest dual affinity for the mu-opioid receptor and I2-IBS affinities.
I2-IBS Binding (bound) of in brain associated with opioid receptor
1) Confidence 0.01 Published 2006 Journal Bioorg. Med. Chem. Section Abstract Doc Link 16797997 Disease Relevance 0 Pain Relevance 0.30

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