INT136550

Context Info Confidence 0.01 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.37 Pain Relevance 0.30

nucleus (FOXI2) transcription factor binding (FOXI2)

Anatomy Link Frequency brain 1 FOXI2 (Homo sapiens)

Pain Link Frequency Relevance Heat opioid receptor 5 100.00 mu opioid receptor 1 94.24 agonist 1 68.80 Analgesic 1 52.16 Central nervous system 1 30.24 narcan 1 25.00

Disease Link Frequency Relevance Heat Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 5 100.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Whereas the BU224 hybrid molecules bound to the mu-opioid receptor and the I2-IBS in the micromolar to low micromolar range, the alkaneguanidine series exhibited remarkable affinities in the nanomolar range for both receptors. [35S]GTPgammaS functional assays were performed on human postmortem brain membranes with selected ligands from each series (4f and 8g) showing the highest dual affinity for the mu-opioid receptor and I2-IBS affinities.

I2-IBS Binding (bound) of in brain associated with opioid receptor

1) Confidence 0.01 Published 2006 Journal Bioorg. Med. Chem. Section Abstract Doc Link 16797997 Disease Relevance 0 Pain Relevance 0.30

General Comments

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