INT136578

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Context Info
Confidence 0.60
First Reported 2004
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.72
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (FOLH1) plasma membrane (FOLH1) nucleus (FOLH1)
cytoplasm (FOLH1)
Anatomy Link Frequency
coronary artery 1
nerve 1
FOLH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 14 99.74 Very High Very High Very High
nMDA receptor 2 92.96 High High
Neuropathic pain 2 91.88 High High
ischemia 12 79.52 Quite High
lidocaine 2 77.20 Quite High
imagery 42 67.76 Quite High
Angina 6 57.20 Quite High
Glutamate receptor 2 38.96 Quite Low
antagonist 2 37.44 Quite Low
Analgesic 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 12 100.00 Very High Very High Very High
Immunization 8 95.84 Very High Very High Very High
Death 2 94.64 High High
Cancer 124 93.72 High High
Neuropathic Pain 2 91.88 High High
Stress 14 91.68 High High
Stroke 2 90.84 High High
Myocardial Infarction 10 88.48 High High
Myocardial Stunning 2 84.48 Quite High
Cv Unclassified Under Development 14 79.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggestion has recently been corroborated by Lieberman and coworkers24 who found that both NAAG release and increase in GCP II activity appear to be induced by electrical stimulation in crayfish nerve fibers and that subsequent NAAG hydrolysis to glutamate contributes, at least in part, to subsequent NMDA receptor activation.
Positive_regulation (increase) of GCP II in nerve associated with glutamate and nmda receptor
1) Confidence 0.60 Published 2006 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 16802724 Disease Relevance 0.22 Pain Relevance 0.39
Measurement of PSMA specific serum antibodies
Positive_regulation (Measurement) of PSMA
2) Confidence 0.49 Published 2004 Journal J Transl Med Section Body Doc Link PMC517950 Disease Relevance 0.16 Pain Relevance 0
Measurement of PSMA specific serum antibodies
Positive_regulation (Measurement) of PSMA
3) Confidence 0.49 Published 2004 Journal J Transl Med Section Body Doc Link PMC517950 Disease Relevance 0.19 Pain Relevance 0.08
The upstream mechanism seems selective for excitotoxic induced glutamate release, as GCP II inhibitors in normal animals induced no change in basal glutamate.
Neg (no) Positive_regulation (induced) of GCP II associated with glutamate
4) Confidence 0.43 Published 2006 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 16802724 Disease Relevance 0.18 Pain Relevance 0.39
In our study, PSM during DSE in patients with chronic coronary artery disease and functional recovery at follow-up was increased compared to that in patients with no functional recovery after successful reperfusion of an occluded coronary artery.
Positive_regulation (increased) of PSM in coronary artery associated with coronary artery disease
5) Confidence 0.14 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2790124 Disease Relevance 0.52 Pain Relevance 0.04
However, PSM of low dose DSE in the presence of functional recovery was significantly increased compared to the group with an absence of functional recovery (Fig. 2).
Positive_regulation (increased) of PSM
6) Confidence 0.10 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2790124 Disease Relevance 0.45 Pain Relevance 0.12

General Comments

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