INT136594

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.16
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2RX4) transport (P2RX4) plasma membrane (P2RX4)
response to stress (P2RX4)
Anatomy Link Frequency
spinal 1
P2RX4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Peripheral nerve injury 1 99.14 Very High Very High Very High
Neuropathic pain 4 98.44 Very High Very High Very High
cytokine 4 94.80 High High
Dorsal horn 1 87.68 High High
Pain 3 79.12 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 2 99.14 Very High Very High Very High
Neuropathic Pain 4 98.44 Very High Very High Very High
Infection 1 93.20 High High
Diabetes Mellitus 1 92.68 High High
Cancer 2 92.28 High High
Necrosis 1 90.88 High High
Injury 1 79.68 Quite High
Pain 2 79.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of the P2X4 receptor, a subtype of ATP receptors, is enhanced in spinal microglia in a peripheral nerve injury model, and blocking pharmacologically and suppressing molecularly P2X4 receptors produces a reduction of the neuropathic pain.
Negative_regulation (suppressing) of P2X4 in spinal associated with nervous system injury, neuropathic pain and peripheral nerve injury
1) Confidence 0.57 Published 2006 Journal Novartis Found. Symp. Section Abstract Doc Link 16805436 Disease Relevance 1.16 Pain Relevance 0.70

General Comments

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