INT136612

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 4.22
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) aging (Nos3) Golgi apparatus (Nos3)
cytoplasm (Nos3) signal transduction (Nos3) oxidoreductase activity (Nos3)
Anatomy Link Frequency
endothelial cells 4
5A1 4
monocyte 3
leucocyte 2
platelet 1
Nos3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 8 100.00 Very High Very High Very High
Sciatic nerve 4 100.00 Very High Very High Very High
Inflammation 18 98.16 Very High Very High Very High
medulla 38 97.44 Very High Very High Very High
Central nervous system 1 78.80 Quite High
metalloproteinase 1 48.60 Quite Low
Neuronal nitric oxide synthase 1 10.48 Low Low
cva 9 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 8 100.00 Very High Very High Very High
Diabetes Mellitus 264 98.72 Very High Very High Very High
INFLAMMATION 22 98.16 Very High Very High Very High
Apoptosis 4 96.24 Very High Very High Very High
Increased Venous Pressure Under Development 1 93.04 High High
Immunization 1 83.40 Quite High
Targeted Disruption 3 60.40 Quite High
Body Weight 20 5.00 Very Low Very Low Very Low
Renal Disease 16 5.00 Very Low Very Low Very Low
Hyperglycemia 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consequently, we postulated that caveolin-1 expression increased in the sciatic nerves with EAN; this possibly mediated either molecular trafficking or nitric oxide generation partly through the activation of eNOS in vascular endothelial cells, as well as in inflammatory macrophages in EAN and/or cellular apoptosis of inflammatory cells.
Positive_regulation (increased) of Positive_regulation (activation) of eNOS in endothelial cells associated with inflammation, sciatic nerve, apoptosis and neuritis
1) Confidence 0.43 Published 2006 Journal Brain Res. Section Abstract Doc Link 16806125 Disease Relevance 1.15 Pain Relevance 0.99
On 9 day after CPA treatment despite of an impairment of the activity of both iNOS and cNOS of platelet and monocyte, the coincident elevation of their citrulline and RNS levels is observed (arginine level of platelet is also increased, whilst that of monocyte is reduced slightly), possibly indicating to an elevation of the NO synthesis.
Positive_regulation (observed) of Spec (possibly) Positive_regulation (impairment) of cNOS in monocyte
2) Confidence 0.37 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0.06 Pain Relevance 0
Of note, the iNOS was increased drastically in platelet, whereas all leucocyte exerted the most pronounced increase in the cNOS activity.
Positive_regulation (exerted) of Positive_regulation (increase) of cNOS in leucocyte
3) Confidence 0.35 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0 Pain Relevance 0
A significant up-regulation of eNOS and iNOS in thoracic aorta in 14-days and 28-days diabetes groups was obtained as compared to control group (Fig 5A1–A3).
Positive_regulation (up) of Positive_regulation (regulation) of eNOS in 5A1 associated with diabetes mellitus
4) Confidence 0.33 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.43 Pain Relevance 0.12
A significant up-regulation of eNOS and iNOS in thoracic aorta in 14-days and 28-days diabetes groups was obtained as compared to control group (Fig 5A1–A3).
Positive_regulation (regulation) of Positive_regulation (up) of eNOS in 5A1 associated with diabetes mellitus
5) Confidence 0.33 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.43 Pain Relevance 0.12
Characterizing a mechanism for netrin-1 induced angiogenesis, a critical role for NO has been elucidated subsequent to feed-forward ERK1/2 and eNOS activation in endothelial cells treated with netrin-1 [25].
Positive_regulation (induced) of Positive_regulation (activation) of eNOS in endothelial cells
6) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.09 Pain Relevance 0.04
On 9 day after CPA treatment despite of an impairment of the activity of both iNOS and cNOS of platelet and monocyte, the coincident elevation of their citrulline and RNS levels is observed (arginine level of platelet is also increased, whilst that of monocyte is reduced slightly), possibly indicating to an elevation of the NO synthesis.
Positive_regulation (observed) of in platelet Spec (possibly) Positive_regulation (impairment) of cNOS in monocyte
7) Confidence 0.13 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0.06 Pain Relevance 0

General Comments

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