INT136613

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.28
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cav1) mitochondrion (Cav1) Golgi apparatus (Cav1)
endoplasmic reticulum (Cav1) intracellular (Cav1) protein complex (Cav1)
Anatomy Link Frequency
macrophages 1
Cav1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 13 99.00 Very High Very High Very High
Neuritis 8 97.72 Very High Very High Very High
Sciatic nerve 4 90.48 High High
antagonist 24 5.00 Very Low Very Low Very Low
Serotonin 10 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
fluoxetine 6 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
sSRI 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 300 99.40 Very High Very High Very High
INFLAMMATION 19 99.00 Very High Very High Very High
Hypertrophy 72 98.96 Very High Very High Very High
Experimental Autoimmune Neuritis 8 97.72 Very High Very High Very High
Immunization 1 88.96 High High
Death 4 48.88 Quite Low
Hypoxia 14 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Apoptosis 9 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry showed that in EAN lesions, intense caveolin-1 immunostaining occurred in ED1-positive macrophages as well as in vessels, while the caveolin-1 immunoreaction was reduced in Schwann cells in the inflammatory lesions.
Negative_regulation (reduced) of caveolin-1 in macrophages associated with inflammation and neuritis
1) Confidence 0.57 Published 2006 Journal Brain Res. Section Abstract Doc Link 16806125 Disease Relevance 0.79 Pain Relevance 0.96
Mice with homozygous deletion of the caveolin-1 (Cav-1) gene develop PAH and RV hypertrophy.
Negative_regulation (deletion) of Cav-1 associated with hypertrophy and pulmonary hypertension
2) Confidence 0.36 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 0.75 Pain Relevance 0
Mice with homozygous deletion of the caveolin-1 (Cav-1) gene develop PAH and RV hypertrophy.
Negative_regulation (deletion) of caveolin-1 associated with hypertrophy and pulmonary hypertension
3) Confidence 0.36 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 0.75 Pain Relevance 0

General Comments

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