INT136614

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Context Info
Confidence 0.46
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.28
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cav1) mitochondrion (Cav1) Golgi apparatus (Cav1)
endoplasmic reticulum (Cav1) intracellular (Cav1) protein complex (Cav1)
Anatomy Link Frequency
sciatic nerves 1
nerve 1
pore 1
Cav1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nav1.6 1 100.00 Very High Very High Very High
Sciatic nerve 10 99.68 Very High Very High Very High
Neuritis 16 98.88 Very High Very High Very High
Calcium channel 1 97.48 Very High Very High Very High
Pain 1 95.80 Very High Very High Very High
ASIC 1 94.56 High High
Inflammation 8 93.92 High High
Spinal cord 4 75.00 Quite High
addiction 8 73.96 Quite High
agonist 8 25.92 Quite Low
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 16 98.88 Very High Very High Very High
Apoptosis 2 98.44 Very High Very High Very High
Pain 1 95.80 Very High Very High Very High
Immunization 2 95.08 Very High Very High Very High
INFLAMMATION 8 93.92 High High
Spasticity 5 75.00 Quite High
Frailty 4 75.00 Quite High
Injury 1 73.04 Quite High
Abnormal Reflex 2 40.64 Quite Low
Spinal Injuries 1 37.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis showed that caveolin-1 significantly increased in the sciatic nerves with EAN upon initiation of cell infiltration during the early and peak stages (days 10 and 14 post-immunization, p.i.) and declined thereafter.
Positive_regulation (increased) of caveolin-1 in sciatic nerves associated with immunization, sciatic nerve and neuritis
1) Confidence 0.46 Published 2006 Journal Brain Res. Section Abstract Doc Link 16806125 Disease Relevance 0.74 Pain Relevance 0.78
The inflammatory cells with intense p-caveolin-1 expression in the EAN-affected individual nerve fascicles were not positive for terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL), while the TUNEL-positive apoptotic cells in the perineurium, where infiltration initially occurred, were weakly positive for p-caveolin-1.
Positive_regulation (positive) of p-caveolin-1 in nerve associated with inflammation, apoptosis and neuritis
2) Confidence 0.41 Published 2007 Journal Brain Res. Section Abstract Doc Link 17234162 Disease Relevance 1.04 Pain Relevance 1.03
The genes of the pore-forming proteins Cav1.3 and Nav1.6 were not up-regulated, whereas genes of proteins such as nonpore-forming subunits and intracellular pathways known to modulate receptor and channel trafficking, kinetics, and conductivity showed marked regulation.
Neg (not) Positive_regulation (up-regulated) of Cav1 in pore associated with nav1.6
3) Confidence 0.33 Published 2010 Journal J. Neurophysiol. Section Abstract Doc Link 19939961 Disease Relevance 0.40 Pain Relevance 0.20
Characterization of inactivation and activation of CaV1.3 channels
Positive_regulation (activation) of CaV1
4) Confidence 0.13 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0 Pain Relevance 0.04
Voltage-gated Ca2+ channels (Cav) are activated by Vm depolarisation and mediate Ca2+ influx into so called "excitable" cells.
Positive_regulation (activated) of Cav
5) Confidence 0.04 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2072944 Disease Relevance 0.10 Pain Relevance 0.19

General Comments

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